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Enhanced electrocaloric effect in ferroelectric ceramics via defect dipole engineering

The authors achieve a high electrocaloric effect in barium titanate ceramics with a defect dipole engineering strategy. As a result, defect dipole engineering enables BaTiO₃ to achieve an electrocaloric effect over a wide temperature range.

Wenrong Xiao
Yao Wu
Guangzu Zhang
ResearchOpen Access07 Oct 2025
Nature Communications

Volume: 16, P: 1-9
Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance

Psychological stress-mediated dysregulation of catecholamine signalling rewires the hepatic kynurenine pathway, which in turn impairs liver CD8⁺ T cell function and promotes liver cancer progression.

Renhui Sun
Deyan Jiao
Xiaohong Liang
Research19 Jan 2026
Nature Metabolism

Volume: 8, P: 196-214
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury

Mitochondria dysfunction contributes to acute liver injuries. Zhang et al. find that Zhx2 deletion enhances mitochondrial function by promoting electron transport chain gene expression via PGC-1α dependent and independent manner.

Yankun Zhang
Yuchen Fan
Chunhong Ma
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-18
Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation

Succinylation, a posttranslational modification on lysine residues, is involved in tumor progression. Here, authors show that PDHA1 K83 succinylation is involved in cholangiocarcinoma tumorigenesis through regulation of macrophage antigen presentation in the tumor microenvironment

Ning Zhang
Linmao Sun
Lianxin Liu
ResearchOpen Access03 Apr 2025
Nature Communications

Volume: 16, P: 1-19
PRC1 as an independent adverse prognostic factor in Wilms tumor via integrated bioinformatics and experimental validation

Yanping Wang
Hongjie Gao
Fengyin Sun
ResearchOpen Access17 Apr 2025
Scientific Reports

Volume: 15, P: 1-17
LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers

Leukaemia inhibitory factor (LIF) is a p53 target but its role in cancer is unclear. Here Hu et al.show that LIF confers chemoresistance in colorectal cancer cells by Stat3-mediated upregulation of inhibitor of DNA-binding 1, leading to MDM2 E3 ubiquitin ligase upregulation and p53 degradation.

Haiyang Yu
Xuetian Yue
Wenwei Hu
Research17 Oct 2014
Nature Communications

Volume: 5, P: 1-12
A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice

An et al. discovered a new brain pathway in mice that conveys light signals from the retina to mood-relevant subcortical nuclei under circadian gating and thereby mediates depressive-like behaviors induced by abnormal nighttime light exposure.

Kai An
Huan Zhao
Tian Xue
Research01 Jun 2020
Nature Neuroscience

Volume: 23, P: 869-880
ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network

Xiaoping Zou
Shuang Nie
Bo Kong
ResearchOpen Access08 Aug 2025
Oncogene

Volume: 44, P: 3774-3786
NaAlTi₃O₈, A Novel Anode Material for Sodium Ion Battery

Xuetian Ma
Ke An
Hailong Chen
ResearchOpen Access13 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis

Yuzhen Wang
Yingchun Wang
Lifen Gao
ResearchOpen Access20 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-13
SHMT2 promotes papillary thyroid cancer metastasis through epigenetic activation of AKT signaling

Min Sun
Mingjian Zhao
Xuetian Yue
ResearchOpen Access25 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-13
Tumor suppressor ZHX2 inhibits NAFLD–HCC progression via blocking LPL-mediated lipid uptake

Zhuanchang Wu
Hongxin Ma
Chunhong Ma
ResearchOpen Access18 Nov 2019
Cell Death & Differentiation

Volume: 27, P: 1693-1708
Circadian-independent light regulation of mammalian metabolism

Rao and Xue discuss emerging evidence in mice and humans of circadian-independent regulation of metabolic responses by light.

Feng Rao
Tian Xue
Reviews03 Jun 2024
Nature Metabolism

Volume: 6, P: 1000-1007
A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis

Xuetian Yue
Yuhan Zhao
Wenwei Hu
ResearchOpen Access01 Nov 2016
Cell Discovery

Volume: 2, P: 1-15
RNA-binding protein 39: a promising therapeutic target for cancer

Caipeng Xu
Xiaohua Chen
Cuixia Di
ReviewsOpen Access13 Aug 2021
Cell Death Discovery

Volume: 7, P: 1-9

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Enhanced electrocaloric effect in ferroelectric ceramics via defect dipole engineering

Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance

ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury

Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation

PRC1 as an independent adverse prognostic factor in Wilms tumor via integrated bioinformatics and experimental validation

LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers

A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice

ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network

NaAlTi₃O₈, A Novel Anode Material for Sodium Ion Battery

TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis

SHMT2 promotes papillary thyroid cancer metastasis through epigenetic activation of AKT signaling

Tumor suppressor ZHX2 inhibits NAFLD–HCC progression via blocking LPL-mediated lipid uptake

Circadian-independent light regulation of mammalian metabolism

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis

RNA-binding protein 39: a promising therapeutic target for cancer

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