Nature Search

Multimodal intelligent reconstruction-driven digital regeneration of cultural heritage in Qing Dynasty tea plantation landscapes

Jue Chen
Xuejuan Dai
Yawen Zeng
ResearchOpen Access17 Jan 2026
npj Heritage Science

Volume: 14, P: 1-18
Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain

Xueding Wang
Yongjiang Pang
Lihong V Wang
Research15 Jun 2003
Nature Biotechnology

Volume: 21, P: 803-806
Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection

Yin, Lin, Cai, Nie and colleagues report phase separation of ERCC6L2 as a mechanism that regulates RNF138-mediated ubiquitination and degradation of CtIP, thereby modulating DNA end resection and treatment response to ATM inhibitors in cancer.

Yixin Yin
Jinlong Lin
Muyan Cai
ResearchOpen Access05 Sept 2025
Nature Cell Biology

Volume: 27, P: 1771-1784
The hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy

Delivering plasmid DNA to solid tumors is challenging since it demands more transport steps than other genetic materials. Here this group designs a hybrid lipoplex for co-delivering p53 plasmid along with MDM2 inhibitor sp141 to hepatocellular carcinoma and lung carcinoma for synergistic anti-tumor treatment.

Xueyi Hu
Yichun Wang
Xintao Shuai
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-20
A deep learning model and human-machine fusion for prediction of EBV-associated gastric cancer from histopathology

Epstein–Barr virus-associated gastric cancer shows a robust response to immune checkpoint inhibitors. Here the authors introduce a deep convolutional neural network and its fusion with pathologists for predicting it from histopathology.

Xueyi Zheng
Ruixuan Wang
Muyan Cai
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-12
A multicenter proof-of-concept study on deep learning-based intraoperative discrimination of primary central nervous system lymphoma

Correct diagnosis of primary central nervous system lymphoma is key in determining treatment, however, this depends on pathology analysis. Here, the authors develop a deep learning method to diagnose primary nervous system lymphoma from stained whole-slide images.

Xinke Zhang
Zihan Zhao
Muyan Cai
ResearchOpen Access04 May 2024
Nature Communications

Volume: 15, P: 1-15
Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons

Addictive substances may impair cognitive flexibility. Here the authors show that in rodents, increased activity of striatal direct-pathway medium spiny neurons (dMSNs) in response to cocaine inhibits cholinergic interneurons (CINs), reducing cognitive flexibility.

Himanshu Gangal
Xueyi Xie
Jun Wang
ResearchOpen Access30 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Hierarchical Li electrochemistry using alloy-type anode for high-energy-density Li metal batteries

Utilizing an ultra-thin Li anode with a thickness below 50 μm is crucial for enhancing the energy density of batteries. Here, the authors develop a finely tunable, thin alloy-based Li anode that features a hierarchical Li electrochemistry, enabling stable cycling and superior energy density in Li metal batteries.

Jiaqi Cao
Yuansheng Shi
Xia Lu
ResearchOpen Access14 Feb 2024
Nature Communications

Volume: 15, P: 1-13
Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Lung adenocarcinomas frequently harbour KRAS mutations, of which a subset are characterized by co-mutation of KEAP1. Here the authors show, in mice, that Kras^G12D mutant tumours are metabolically distinct, with a bronchiolar cell-of-origin.

Sarah A. Best
Sheryl Ding
Kate D. Sutherland
ResearchOpen Access13 Sept 2019
Nature Communications

Volume: 10, P: 1-14
Traumatic brain injury exacerbates alcohol consumption and neuroinflammation with decline in cognition and cholinergic activity

Himanshu Gangal
Jaclyn Iannucci
Jun Wang
ResearchOpen Access16 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-11
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
An end-to-end multifunctional AI platform for intraoperative diagnosis

Xueyi Zheng
Ke Zheng
Muyan Cai
ResearchOpen Access20 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-12
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

Min Tang
Qi Xie
Jeremy N. Rich
Research04 Jun 2020
Cell Research

Volume: 30, P: 833-853

Search

Multimodal intelligent reconstruction-driven digital regeneration of cultural heritage in Qing Dynasty tea plantation landscapes

Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain

Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection

The hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy

A deep learning model and human-machine fusion for prediction of EBV-associated gastric cancer from histopathology

A multicenter proof-of-concept study on deep learning-based intraoperative discrimination of primary central nervous system lymphoma

Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons

Hierarchical Li electrochemistry using alloy-type anode for high-energy-density Li metal batteries

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Traumatic brain injury exacerbates alcohol consumption and neuroinflammation with decline in cognition and cholinergic activity

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

An end-to-end multifunctional AI platform for intraoperative diagnosis

Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

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