Nature Search

Next generation of tumor-activating type I IFN enhances anti-tumor immune responses to overcome therapy resistance

Several studies have demonstrated that IFN-I administration can boost anti-tumor immune response against solid tumors. Here, to overcome the limitations of systemic IFN-I therapy (side effects, short half-life), the authors design a masked IFN-I prodrug activatable by tumor-associated proteases, showing preserved anti-tumor activity but reduced toxicity.

Xuezhi Cao
Yong Liang
Yang-Xin Fu
ResearchOpen Access07 Oct 2021
Nature Communications

Volume: 12, P: 1-11
Functionally deficient UBOX5 variants and primary angle-closure glaucoma

Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

Zheng Li
Wee Ling Chng
Chiea Chuen Khor
ResearchOpen Access15 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Dysbiosis of gut microbiota in children with functional constipation and damp-heat constitution: a cross-sectional multi-omics analysis

Haihong Zhao
Xiuxia Lu
Ji Wang
ResearchOpen Access26 Nov 2025
Scientific Reports

Volume: 15, P: 1-16
A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy

While recognized as the first effective immunotherapy for human cancer, IL-2 based immunotherapy still encounters several limitations in the clinic. Here, the authors design a cytokine receptor-masked IL-2 mutein prodrug that is selectively activated by matrix metalloproteinases in the tumor microenvironment, promoting anti-tumor immune response while minimizing systemic toxicity.

Eric J. Hsu
Xuezhi Cao
Yang-Xin Fu
ResearchOpen Access13 May 2021
Nature Communications

Volume: 12, P: 1-13
Author Correction: Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

Chuanhui Han
Zhida Liu
Yang-Xin Fu
Amendments and Corrections16 Sept 2020
Nature Immunology

Volume: 21, P: 1470
The Li-ion battery industry and its challenges

The lithium-ion battery industry is driving the global clean energy transition but faces growing sustainability challenges. Pollution and recycling bottlenecks span the entire materials life cycle, emphasizing the urgent need for integrated chemical, environmental and policy frameworks to guide risk assessments and sustainable development.

Xuezhi Yang
Haiyan Zhang
Guibin Jiang
Comments & Opinion11 Jul 2025
Nature Reviews Chemistry

Volume: 9, P: 497-498
Directly transforming copper (I) oxide bulk into isolated single-atom copper sites catalyst through gas-transport approach

Single-atom catalysts attract lots of attention, but direct transformation of bulk metal oxide into single atoms remains challenging. Here the authors report a gas-transport route to transform monolithic copper (I) oxide into copper single-atoms catalyst with a high activity for oxygen reduction.

Zhengkun Yang
Bingxu Chen
Yuen Wu
ResearchOpen Access19 Aug 2019
Nature Communications

Volume: 10, P: 1-7
GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model

Xiaodong Yang
Guole Liu
Xin Li
ResearchOpen Access08 Oct 2024
Cell Research

Volume: 34, P: 830-845
Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion

Exposure to ambient particulate matter is one of the leading global health risks. Here, the authors reveal, by means of chemical multi-fingerprinting, the presence of exogenous ultrafine particles with diverse species and morphology in non-occupational human serum and pleural effusion.

Dawei Lu
Qian Luo
Guibin Jiang
ResearchOpen Access22 May 2020
Nature Communications

Volume: 11, P: 1-8
Synthesis of piperidines and pyridine from furfural over a surface single-atom alloy Ru₁Co_NP catalyst

The synthesis of nitrogen-containing heterocycles from biomass is scarcely known. Here, the authors report a strategy for the N-heterocyclic piperidines synthesis by one-pot amination of the bio-based furfural utilizing a Ru₁Co_NP/HAP surface single-atom alloy catalyst.

Haifeng Qi
Yurou Li
Tao Zhang
ResearchOpen Access10 Oct 2023
Nature Communications

Volume: 14, P: 1-10
Distinguishing the sources of silica nanoparticles by dual isotopic fingerprinting and machine learning

Determining the source of nanoparticles is critical for nanotechnology risk assessment. Here, the authors develop an approach that, by taking into account the isotopic signatures of both Si and O, may be able to distinguish between natural and engineered SiO2 nanoparticles, and even those synthesized by different manufacturers.

Xuezhi Yang
Xian Liu
Guibin Jiang
ResearchOpen Access08 Apr 2019
Nature Communications

Volume: 10, P: 1-9
Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells

Hu, Tan, Chia et al. identify negative elongation factor A as one of the earliest drivers of the mouse embryonic 2-cell-like state through interaction with Top2a, which mediates Dux expression.

Zhenhua Hu
Dennis Eng Kiat Tan
Wee-Wei Tee
Research13 Jan 2020
Nature Cell Biology

Volume: 22, P: 175-186
Contribution of human and climate change impacts to changes in streamflow of Canada

Xuezhi Tan
Thian Yew Gan
ResearchOpen Access04 Dec 2015
Scientific Reports

Volume: 5, P: 1-10
Structural Phase Transition of ThC Under High Pressure

Cun Yu
Jun Lin
Hongjie Xu
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-5
Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

Therapeutic irradiation can trigger DNA-sensing pathways and trigger antitumor immunity. Fu and colleagues demonstrate that tumors can co-opt intrinsic apoptotic pathways to avoid immunogenic cell death following irradiation.

Chuanhui Han
Zhida Liu
Yang-Xin Fu
Research30 Mar 2020
Nature Immunology

Volume: 21, P: 546-554
Optimizing co-expression strategies for the simultaneous display and secretion of monoclonal antibodies in CHO cells

Jessica P. Z. Ng
Mariati Mariati
Yuansheng Yang
ResearchOpen Access27 Nov 2025
Scientific Reports

Volume: 15, P: 1-13
Molecular-level insights into the electronic effects in platinum-catalyzed carbon monoxide oxidation

A molecular-level understanding of the electronic effects remains a grand challenge in heterogeneous catalysis. Here, the authors report an unconventional kinetics strategy for bridging the upscaling gap between the microscopic fingerprints of active sites and the macroscopic catalytic performance.

Wenyao Chen
Junbo Cao
Xuezhi Duan
ResearchOpen Access25 Nov 2021
Nature Communications

Volume: 12, P: 1-11
Diverse lattice dynamics in ternary Cu-Sb-Se compounds

Wujie Qiu
Lihua Wu
Wenqing Zhang
ResearchOpen Access02 Sept 2015
Scientific Reports

Volume: 5, P: 1-7
Construction and analysis of China’s carbon emission model based on machine learning

Jian Sun
Xinzi Wang
Xuezhi Liu
ResearchOpen Access17 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Long-term exposure to a ‘safe’ dose of bisphenol A reduced protein acetylation in adult rat testes

Zhuo Chen
Xuezhi Zuo
Chenjiang Ying
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
A semi-mechanistic aging model of Pb added to soil by a modified stable isotope dilution technique

Xuezhi Ji
Jumei Li
Yibing Ma
ResearchOpen Access12 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
Mechanism exploration and model construction for small cell transformation in EGFR-mutant lung adenocarcinomas

Yan Li
Tongji Xie
Puyuan Xing
ResearchOpen Access02 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-13
Study on surface quality of GH4169 superalloy milling with ultrasonic synergistic nanofluid minimal quantity lubrication

Xuezhi Wang
Zixiang Mei
Minghai Wang
ResearchOpen Access14 May 2025
Scientific Reports

Volume: 15, P: 1-19
Retraction Note: Long noncoding RNA HEIH depletion depresses esophageal carcinoma cell progression by upregulating microRNA-185 and downregulating KLK5

Bing Wang
Xuezhi Hao
Yushun Gao
Amendments and CorrectionsOpen Access18 Dec 2023
Cell Death & Disease

Volume: 14, P: 1
Dynamics-constrained rainfall projection reveals substantial increase in population exposure to unprecedented floods in the North China Plain

The North China Plain is experiencing a nearly fivefold increase in population exposure to moderate and high flood depth due to increased rainfall and favorable synoptic conditions, according to a methodology that combines large ensemble climate model outputs with dynamic downscaling simulations.

Long Yang
Jinghan Zhang
Fuqiang Tian
ResearchOpen Access19 Jun 2025
Communications Earth & Environment

Volume: 6, P: 1-12
Mechanisms of rainfall-induced landslides and interception dynamic response: a case study of the Ni changgou landslide in Shimian, China

Yu Li
Xuezhi Yang
Erlong Ma
ResearchOpen Access18 Jan 2024
Scientific Reports

Volume: 14, P: 1-24
RETRACTED ARTICLE: Long noncoding RNA HEIH depletion depresses esophageal carcinoma cell progression by upregulating microRNA-185 and downregulating KLK5

Bing Wang
Xuezhi Hao
Yushun Gao
ResearchOpen Access22 Nov 2020
Cell Death & Disease

Volume: 11, P: 1-14
Genomic diversity and transmission patterns of Yersinia pestis in Inner Mongolia Autonomous Region, China

Analysis of the genomes and spatiotemporal distribution of Yersinia pestis in Inner Mongolia, China, reveals its genetic diversity and dual transmission patterns, including localized short-distance spread and long-distance dispersals.

Xiujuan Zuo
Fang Liu
Yujun Cui
ResearchOpen Access09 Nov 2024
Communications Biology

Volume: 7, P: 1-8
Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma

Yang Yu
Mingjiong Zhang
Lin Miao
ResearchOpen Access03 Jul 2018
Cell Death & Disease

Volume: 9, P: 1-13
CP-25, a novel compound, protects against autoimmune arthritis by modulating immune mediators of inflammation and bone damage

Yan Chang
Xiaoyi Jia
Wei Wei
ResearchOpen Access17 May 2016
Scientific Reports

Volume: 6, P: 1-13
HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Laiqiang Chen
Yiyang Qin
Su Yang
ResearchOpen Access14 May 2024
Cell Death & Disease

Volume: 15, P: 1-13
Behaviors of Glioblastoma Cells in in Vitro Microenvironments

Wenwen Diao
Xuezhi Tong
Zhong-Can Ou-Yang
ResearchOpen Access14 Jan 2019
Scientific Reports

Volume: 9, P: 1-9
Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects

Chunmei Wen
Qingqing Ruan
Jie Deng
Research13 Oct 2022
British Journal of Cancer

Volume: 127, P: 2108-2117
MiR-146a regulates regulatory T cells to suppress heart transplant rejection in mice

Jian Lu
Weiwei Wang
Feng Qi
ResearchOpen Access17 Jun 2021
Cell Death Discovery

Volume: 7, P: 1-12
Critical roles of TRPV2 channels, histamine H1 and adenosine A1 receptors in the initiation of acupoint signals for acupuncture analgesia

Meng Huang
Xuezhi Wang
Guanghong Ding
ResearchOpen Access25 Apr 2018
Scientific Reports

Volume: 8, P: 1-11
Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer

Heng Liang Tan
Charlene Yong
Andre Choo
ResearchOpen Access02 Aug 2018
Scientific Reports

Volume: 8, P: 1-11
Non-adjuvanted interferon-armed RBD protein nasal drops protect airway infection from SARS-CoV-2

Yifan Lin
Jing Sun
Hua Peng
CorrespondenceOpen Access10 May 2022
Cell Discovery

Volume: 8, P: 1-4
Genetic signatures of high-altitude adaptation and geographic distribution in Tibetan sheep

Jianbin Liu
Chao Yuan
Bohui Yang
ResearchOpen Access27 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis

Wenli Li
Xiaolan Tian
Guochun Wang
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
A comprehensive CHO SWATH-MS spectral library for robust quantitative profiling of 10,000 proteins

Kae Hwan Sim
Lillian Chia-Yi Liu
Xuezhi Bi
ResearchOpen Access11 Aug 2020
Scientific Data

Volume: 7, P: 1-13

Search

Filter By:

Search

Quick links