Epithelial-mesenchymal transition (EMT) is a common mechanism for acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Here, the authors discover that ZEB1-mediated repression of ELMO3 creates a synthetic-lethal dependence on ELMO2, and that inhibiting ELMO2 selectively kills mesenchymal-like cells and EGFR TKIs–resistant cancer cells.
- Min Li
- Ying Xue
- Qihong Huang
