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Wearable intelligent throat enables natural speech in stroke patients with dysarthria

Wearable silent speech systems hold potential for restoring communication in patients suffering from speech impairments. Tang et al. report an AI-driven silent speech system for dysarthria patients, which enables zero-time-delay expression and context-aware emotion decoding-based sentence expansion.

Chenyu Tang
Shuo Gao
Luigi G. Occhipinti
ResearchOpen Access19 Jan 2026
Nature Communications

Volume: 17, P: 1-12
Aberrant adenosine A_2A receptor signaling in the choroid plexus drives CSF hypersecretion and ventriculomegaly in hydrocephalus

This study identifies adenosine A_2A receptor (A_2AR) signaling in the choroid plexus as a key driver of cerebrospinal fluid hypersecretion and ventriculomegaly in hydrocephalus. Pharmacological or genetic inhibition of choroid plexus A_2AR mitigates disease pathology, highlighting A_2AR antagonism as a promising therapeutic strategy for hydrocephalus.

Wu Zheng
Lanxin Hu
Jiang-Fan Chen
ResearchOpen Access07 Dec 2025
Nature Communications

Volume: 17, P: 1-15
Artefacts in continuous neuromonitoring

Continuous neuromonitoring is vital for guiding neurocritical care, yet artefacts frequently obscure cerebral physiological signals and hinder clinical decisions. In this Review, sources of artefacts and their clinical impact are examined, alongside emerging strategies — both knowledge-based and data-driven — for artefact mitigation, sensor design and artificial intelligence-enabled real-time monitoring in precision neurocare.

Xuhang Chen
Stefan Yu Bögli
Peter Smielewski
Reviews06 Jan 2026
Nature Reviews Bioengineering

P: 1-15
Structural insights into the activation mechanism of the human zinc-activated channel

ZAC is a Zn²⁺ and H⁺-activated cation channel. Here, the authors report the structures of human ZAC and identify an unusual C-tail that functions in auto-inhibition. This work provides insights into the gating and activation mechanisms of ZAC.

Xuhang Lu
Dongmei Li
Yuequan Shen
ResearchOpen Access07 Jan 2025
Nature Communications

Volume: 16, P: 1-12
Integrative proteogenomic characterization reveals therapeutic targets in poorly differentiated and anaplastic thyroid cancers

The treatment of poorly differentiated thyroid cancer and anaplastic thyroid cancer remains challenging. Here, the authors perform multi-omic analysis of thyroid samples and identify proteomic clusters associated with distinct tumour microenvironment features.

Zongfu Pan
Zhuo Tan
Minghua Ge
ResearchOpen Access16 Apr 2025
Nature Communications

Volume: 16, P: 1-20
RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis

In this work, authors elucidate the molecular mechanisms by which neonatal meningitis Escherichia coli facilitates bacterial invasion through inducing multiple programmed cell death pathways in brain microvascular endothelial cells.

Xuhang Wang
Yuhan Zhang
Fang Tang
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3

Two mGlu3–βarr1 cryo-EM structures with 2:1 and 2:2 stoichiometries are reported, revealing that the inactive state involves mGlu3 engagement of βarr1 through phosphorylated C-terminal tail and intracellular loops.

Tianlei Wen
Mei Du
Xue Yang
Research06 Mar 2025
Nature Chemical Biology

Volume: 21, P: 1262-1269
Scalable production of ultraflat and ultraflexible diamond membrane

Edge-exposed exfoliation using sticky tape is shown to be a simple and reliable method for scaling up the production of ultrathin, ultraflat and ultraflexible polycrystalline diamond membranes for diverse electrical, optical, mechanical, thermal, acoustic and quantum applications.

Jixiang Jing
Fuqiang Sun
Zhiqin Chu
Research18 Dec 2024
Nature

Volume: 636, P: 627-634
Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

The DNA ligase of African swine fever virus is one of the most error-prone ligases identified to date, but underlying molecular details are lacking. Here, Chen et al. report four AsfvLIG:DNA structures and identify a unique N-terminal domain and four unique active site residues that are crucial for its catalytic efficiency.

Yiqing Chen
Hehua Liu
Jianhua Gan
ResearchOpen Access23 Jan 2019
Nature Communications

Volume: 10, P: 1-13
BET protein inhibition evidently enhances sensitivity to PI3K/mTOR dual inhibition in intrahepatic cholangiocarcinoma

Xiaolong Miao
Chen Liu
Weihua Gong
ResearchOpen Access29 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-12

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Wearable intelligent throat enables natural speech in stroke patients with dysarthria

Aberrant adenosine A_2A receptor signaling in the choroid plexus drives CSF hypersecretion and ventriculomegaly in hydrocephalus

Artefacts in continuous neuromonitoring

Structural insights into the activation mechanism of the human zinc-activated channel

Integrative proteogenomic characterization reveals therapeutic targets in poorly differentiated and anaplastic thyroid cancers

RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis

Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3

Scalable production of ultraflat and ultraflexible diamond membrane

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

BET protein inhibition evidently enhances sensitivity to PI3K/mTOR dual inhibition in intrahepatic cholangiocarcinoma

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