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Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment

Spatial molecular imaging analysis of human pancreatic adenocarcinomas describes multicellular neighborhoods in the tumor microenvironment. Ligand–receptor analysis using optimal transport-based SCOTIA identifies interleukin-6 as a mediator of chemoresistance.

Carina Shiau
Jingyi Cao
William L. Hwang
Research03 Sept 2024
Nature Genetics

Volume: 56, P: 2466-2478
Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events

Li Chen
Iulian Pruteanu-Malinici
Cyril H. Benes
ResearchOpen Access24 Jan 2025
Scientific Reports

Volume: 15, P: 1-12

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Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment

Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events

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