An oxidative activation strategy using pyridyl phosphonium salts and potassium persulfate is reported. This approach, which governs the reaction pathway, enables the synthesis of C4-fluorinated and C4-trifluoromethylaminated pyridines with a broad functional group tolerance and is used for the late-stage synthesis and modification of bioactive molecules.
- Longhui Chen
- Chenming Zu
- Pingping Tang
