Nature Search

Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations

Oesophageal squamous-cell carcinoma (ESCC) is a leading cause of cancer death, and half of ESCC cases occur in China. Here, the authors provide an in depth genomic landscape for this disease and identify specific mutation signatures—one of which is linked to alcohol intake.

Jiang Chang
Wenle Tan
Dongxin Lin
ResearchOpen Access26 May 2017
Nature Communications

Volume: 8, P: 1-11
Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial

In a prespecified interim analysis of the multicenter, randomized, phase 3 FLAMES trial, maintenance therapy with a PARP inhibitor in patients with ovarian cancer showed prolonged progression-free survival compared with placebo in all subgroups defined by BRCA or homologous recombination status.

Xiaohua Wu
Jihong Liu
Linjuan Zeng
Research15 May 2024
Nature Medicine

Volume: 30, P: 1612-1621
The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming

The transcription factor c-Myc is a master regulator of cellular metabolism and has an important role in tumorigenesis. Phanet al. show that 14-3-3σ, an inhibitor of cell cycle progression, also suppresses tumour-promoting metabolic programmes by promoting the degradation of c-Myc.

Liem Phan
Ping-Chieh Chou
Mong-Hong Lee
Research16 Jul 2015
Nature Communications

Volume: 6, P: 1-16
Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation

Dongxin Lin, Chen Wu and colleagues identify a LINC00673 variant that associates with pancreatic cancer risk in Han Chinese cohorts. They show that the variant creates a target site for miR-1231 and that LINC00673 regulates PTPN11 degradation and leads to altered SRC–ERK and STAT1-dependent signaling.

Jian Zheng
Xudong Huang
Dongxin Lin
Research23 May 2016
Nature Genetics

Volume: 48, P: 747-757
The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm

Weihao Huang
Jing Shi
Zhiren Wang
ResearchOpen Access20 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population

Dongxin Lin and colleagues report a genome-wide association study for laryngeal squamous cell carcinoma (LSCC) in Chinese populations. They identify three loci newly associated with LSCC.

Qingyi Wei
Dianke Yu
Dongxin Lin
Research07 Sept 2014
Nature Genetics

Volume: 46, P: 1110-1114
Identifying key genes in milk fat metabolism by weighted gene co-expression network analysis

Tong Mu
Honghong Hu
Yaling Gu
ResearchOpen Access27 Apr 2022
Scientific Reports

Volume: 12, P: 1-13
COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

The presence of cardiovascular comorbidities is linked with worse outcomes in patients with coronavirus disease 2019 (COVID-19), and COVID-19 can induce cardiovascular damage. In this Review, Wu and colleagues summarize the latest mechanistic and clinical studies that contribute to our current understanding of COVID-19-related cardiovascular disease.

Masataka Nishiga
Dao Wen Wang
Joseph C. Wu
Reviews20 Jul 2020
Nature Reviews Cardiology

Volume: 17, P: 543-558
Simvastatin accelerated motoneurons death in SOD1^G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles

Lin Bai
Yafei Wang
Rui Li
ResearchOpen Access12 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-17
Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity

Chih-Chao Hsu
Dan Zhao
Xiaobing Shi
ResearchOpen Access12 Jun 2018
Cell Discovery

Volume: 4, P: 1-17
Correction: Simvastatin accelerated motoneurons death in SOD1^G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles

Lin Bai
Yafei Wang
Rui Li
Amendments and CorrectionsOpen Access27 Feb 2025
Cell Death & Disease

Volume: 16, P: 1-5
PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses

Chencheng Xiao
Wenjun Ma
Ming Liao
ResearchOpen Access19 Jan 2016
Scientific Reports

Volume: 6, P: 1-13
Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

Yaling Yin
Yali Wang
Jian-Zhi Wang
ResearchOpen Access09 Jun 2016
Scientific Reports

Volume: 6, P: 1-11

Search

Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations

Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial

The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming

Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation

The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm

Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population

Identifying key genes in milk fat metabolism by weighted gene co-expression network analysis

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

Simvastatin accelerated motoneurons death in SOD1^G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles

Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity

Correction: Simvastatin accelerated motoneurons death in SOD1^G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles

PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses

Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

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