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Developing sustainable adhesives with simultaneous high adhesive strength and excellent work of debonding remains challenging. Here, the authors report a strong, ultra-tough, and recyclable polyurethane adhesives using a multiscale engineering approach.

Wu et al. show that cooperative coupling at buried and top perovskite interfaces promotes chemically bonded self-assembled monolayers and forms a stable 1D heterojunction, enabling perovskite solar cells with 27.05% efficiency and maintaining over 95% of the efficiency after 2,100-hour continuous operation at 65 °C.

Research on dualities is commonly restricted to one-to-one mappings. Here, by incorporating artificial gauge fields, the authors demonstrate 2D and 3D acoustic metamaterials enabling ℤ₂ × ℤ₂ and (ℤ₂)⁶ duality groups, respectively, where distinct structures share identical band structures, and self-duality gives rise to symmetry-protected high-order degeneracies.

Dysregulated CD59 drives uncontrolled complement activation in neuromyelitis optica spectrum disorders (NMOSD). Here, the authors show in a mouse NMOSD model that endothelial SPARC suppresses astrocytic CD59 by blocking the VEGFA/VEGFR2 axis, promoting astrocytopathy, that might offer a potential therapeutic strategy.

ZAT-DNA encodes data in A/Z base patterns that PCR erases, ensuring molecular non-replicability. It enables secure 32/64-bit key storage and nanopore retrieval, blocks copying, and protects NFTs. The Babel-DNA hybrid allows selective access to multiple encrypted datasets from a single DNA pool using unique ZAT-DNA keys.

Mucosal melanoma is a rare and aggressive subtype which, unlike cutaneous melanoma, shows limited response to immune checkpoint inhibition. Here, the authors report the safety and efficacy of neoadjuvant pembrolizumab (anti-PD-1) and lenvatinib (multi tyrosine kinase inhibition) in patients with resectable mucosal melanoma, along with exploratory biomarker analysis.

Valine metabolism disruption is linked to heart disease, but the mechanisms are unclear. Here, the authors show that ACAD8 deficiency drives isobutyryl-CoA accumulation and histone isobutyrylation, increasing chromatin accessibility and gene expression to promote cardiac hypertrophy, while ACAD8 overexpression reverses these effects.

The authors report a first-order phase transition within the superconducting state of multilayer thin flakes of 2H-NbSe2 via tunneling spectroscopy. They interpret this as thermodynamic evidence for the orbital Fulde-Ferrell-Larkin-Ovchinnikov state.

Clinical success of fecal microbiota transplantation depends on donor microbe engraftment. Here, the authors show that inorganic nitrogen utilization capacity drives gut microbiome remodeling and that boosting this function enhances donor microbe engraftment and improved colitis treatment in mice.

Precise transcription-repair coordination is required for efficient DSB repair. Here, the authors show that DNA-PK-mediated CRTC2 Ser433 phosphorylation, relocates DNA-PK from transcription to repair complexes and promote NHEJ. Inhibition of CRTC2 sensitizes liver cancer to radioimmunotherapy.

Chronic stress has been reported to have a role in tumour progression via activation of the sympathetic nervous system. Here, the authors develop a biomimetic nanovesicle for tumour microenvironment specific delivery of the β-adrenergic receptor blocker, propranolol, to enhance pancreatic cancer chemotherapy by disrupting sympathetic nerve-tumour crosstalk under chronic stress exposure

Neogene lithium isotope records from the Tibetan Plateau suggest that silicate weathering in mountain ranges may not persistently contribute sufficient lithium into the ocean to regulate seawater lithium isotope evolution

The authors report ambient-pressure, polarization-resolved electronic Raman scattering measurements on single crystals of nickelate La₃Ni₂O₇, which becomes superconducting under pressure. Quantitative analysis reveals momentum-selective spin density wave (SDW) gap amplitudes, indicating an unconventional SDW driven by anisotropic electronic correlations.

Changhua County, Taiwan launched a hepatitis C elimination initiative which integrates population-based screening and targeted strategies for high-risk groups. Here, the authors evaluate its impacts on hepatitis C virus cascade care and treatment outcomes and compare to a counterfactual scenario without the program.

The malto-oligosaccharides (MOS) serve as essential primers for starch synthesis in higher plants. Authors demonstrate that two enzymes, PHS1 and DPE1, form a binary complex and coordinately promote MOS synthesis as a key initial step in starch biosynthesis.

Owing to the lack of precise atomic-level control offered by existing fabrication techniques over the edge structures in bilayer graphene, experimental studies on the edge effects in bilayer graphene structures have so far largely remained unexplored. Here the authors synthesize two fully cove-edged bilayer nanographenes and demonstrate their application in NIR-II bioimaging.

Preeclampsia results from abnormal placentation, but the role of protein O-fucosylation is unclear. Here the authors show that poFUT1 loss reduces EDIL3 O-fucosylation, disrupts LIFR–STAT3 signaling, and causes defective placental remodeling and PE-like phenotypes.

Replicating the human brain’s imaginative ability has long been a core AI goal, yet current systems remain limited in speed and efficiency. Yang et al. present a hardware platform based on resistive memory, enabling high-speed, low-power AI content generation while fully preserving output quality.

The CLAVATA3 (CLV3)-WUSCHEL (WUS) feedback loop functions in shoot apical meristem maintenance. Liu et al. (2026) discovered that kinase Casein Kinase II act as nuclear effectors of G protein, linking CLV3 perception to WUS transcription.

Three-dimensional spatial coding in the primate brain is poorly understood. Here the authors identified spatially tuned neurons in marmoset frontal cortex and hippocampus during free foraging behavior in a 3D space.

Immunosuppressive tumor-associated macrophages (TAM) contribute to resistance to immune checkpoint blockade. Here, the authors propose BCAT1 to inhibit crotonate-mediated epigenetic reprogramming of tumor-associated macrophages, with BCAT1 loss promoting immune escape in hepatocellular carcinoma mouse models.

Changing a catalyst’s surface via strain can alter how strongly it binds reacting molecules, but this does not help every metal equally. This study shows that magnetism can offset strain, limiting gains in strongly magnetic metals and guiding better catalyst design.

In this work, the authors show that the uncharacterized protein YchJ acts as a ROS-sensing transcription factor in Salmonella; upon oxidation, YchJ dimerization represses rssB, stabilizing RpoS to activate antioxidant enzymes, protecting the pathogen from macrophage oxidative burst.

This study identifies a mitochondrial protection pathway that safeguards mitochondrial DNA integrity and limits liver damage. Disrupting this pathway triggers inflammation and fibrosis, while restoring protection or inhibiting DNA sensing markedly ameliorates fatty liver disease.

The substrate surface engineering approach prevents the formation of twin structures, while the elimination of twins greatly enhances carrier mobility and suppresses bipolar conduction, leading to optimized power factor in twin-free Bi₂Te₃ films.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Rechargeable Li | |SOCl₂ battery performance is hindered by inadequate catalyst activity at the electrode. Here, authors utilize covalent organic frameworks with aligned pores and tailored chemistry to create localized high concentrations of iodine catalyst, achieving stable high-capacity cycling and good practical pouch cell performance.

Polymer nanocomposites face a fundamental challenge in simultaneously enhancing strength and toughness, as current methods often compromise one for the other. Here the authors incorporate mechanically interlocked [2]rotaxane units into the interfacial layer of dynamically cross-linked polymer nanocomposites to enhance both strength and toughness.

DNA replication initiation requires precise MCM2-7 assembly. Here, the authors reveal cryo-EM structures of human MCM2-7 showing unique roles of its C-terminal extensions, defining how flexible yet accurate helicase loading ensures genome-wide replication initiation.

Amorphous chalcogenides enable ultrafast threshold switching, yet their switching mechanism remains debated between electronic and structural models. Song et al. reveal an electric field induced atomic displacement and dipolar ordering, which exhibit a non-Arrhenius structural transition and guide conductive filament formation.

Concentration polarization limits cycling stability of cells at high currents. Here, authors propose a mechanical-electrochemical conversion strategy by constructing a piezo electrolyte that actively utilizes the unavoidable volume fluctuation of lithium metal to minimize concentration polarization.

Here, the authors uncover a mechanism by which drug-target homologs mediate non-antibiotic drug effects on bacterial growth, and suggest a universal homology-based competition strategy to reverse MTX-induced microbiota dysbiosis.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Direct ethylene epoxidation with water is green but limited by poor ethylene capture and unstable intermediates. Here, the authors report a strained CuO–Ag heterojunction that enhances ethylene adsorption and stabilizes oxygen species via charge oscillations, enabling efficient epoxidation.

Liu et al. show some non-symbiotic NIN orthologues can function in nodule symbiosis, indicating this ability predates nodulation. Analyses of subcellular localization and evolutionary conservation reveal symbiotic refinement of NIN after recruitment.

Single-component organic solar cells are more stable than blends but suffer limited efficiency from inefficient charge generation. Li et al. introduce a fluorinated double-cable polymer that accelerates charge transfer and separation, achieving 14.8% efficiency and higher photocurrent.

The authors report a centimeter-scale untethered tripodal robot with three radial piezoelectric actuators for omnidirectional locomotion without attitude turning and cross-scale precision, enabling autonomous navigation and micro-macro inspection.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

Excess free fatty acids are toxic to cells. Here, the authors identify TMEM120A as a GPAT4 activator that promotes the incorporation of medium- and long-chain fatty acids into glycerolipids to prevent lipotoxicity.

Coordination materials play a pivotal role in advancing multidisciplinary fields within contemporary science. Here, the authors present a heterogeneous in situ approach that employs zero-valent metal as a cation source in aqueous media, coupled with linker supersaturation, as a scalable synthesis process for the discovery of crystalline coordination materials.

Traditional bisphenol A diglycidyl ether (BADGE) synthesis from bisphenol A and epichlorohydrin using NaOH suffers from side reactions, low purity product and high viscosity. Here, the authors report an organocatalytic NaOH-free route, yielding higher purity BADGE and improved epoxy resins.

High-performance perovskite tandem solar cells are limited by uneven, disordered self-assembled monolayer (SAM) acting as hole-selective layers. Luo et al. design a SAM that yields uniform, stable interfaces, reducing non-radiative losses and boosting efficiency and durability

A multiphase-flow-guided solar evaporator integrates water replenishment, vapor dissipation, salt reflux, and heat management, enabling ultrahigh-efficiency solar desalination with stable operation in ~15 wt.% saline water and high daily freshwater production under natural sunlight.

Traditional single-cell models often overlook the proteomic context of cell phenotypes. Here, authors present CAPTAIN, a multimodal foundation model pretrained on 4.2 million cells. It aligns RNA and protein profiles to enhance cell annotation, protein imputation, and intercellular discovery.

This study shows that the UMOD p.H36Y mutation promotes kidney inflammation by enabling mutant tubular cells to trigger macrophage pyroptosis through the App–Cd74 pathway.

Recycling polycarbonate plastics is energy intensive and depends on excess methanol. This work couples plastic breakdown with glycerol conversion to regenerate methanol in situ, reducing energy use while achieving high yields at pilot scale.