Macrophages and lipid metabolism have an important function in atherosclerosis. Here, the authors characterise the function of chitinase-like protein 3 (CHIL3) or its human functional homologue chitinase-3-like 2 (CHI3L2), and show these proteins enhance atherogenesis in a macrophage dependent manner and function by hydrolysing glycans on CD36 which enhances lipid uptake, activates mTOR and inflammatory macrophage responses and suppresses PPARγ-ABCG1-mediated cholesterol efflux.
- Yu Wang
- Jing Zhang
- Wenhua Zhu