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Showing 1–4 of 4 results
Advanced filters: Author: Yanik Weber Clear advanced filters

  • Photosensory protein domains, derived from nature, are foundational for optogenetic protein engineering. Here the authors develop a high-throughput strategy to tune the light sensitivity and activation of a widely used optogenetic protein system.

    • Armin Baumschlager
    • Yanik Weber
    • Mustafa Khammash
    ResearchOpen Access
    Nature Communications
    P: 1-16

  • This study finds that prime editing of Adrb1A187V in the mouse brain boosts excitability of β1- adrenergic neurons, wake behaviors, and memory, while lowering sleep pressure. In an Alzheimer’s model, Adrb1A187V also restored physiological REM sleep amounts.

    • Desirée Böck
    • Lisa Tidecks
    • Gerald Schwank
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Compared to traditional Cas9 nucleases prime editors (PEs) are less active. Here the authors use OrthoRep, a yeast-based platform for directed protein evolution to enhance the editing efficiency of PEs: they identify mutations that have a positive effect on kinetics and use this knowledge to generate an efficient in vivo PE.

    • Yanik Weber
    • Desirée Böck
    • Gerald Schwank
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11