Nature Search

Comprehensive evaluation of GLP-1 receptor agonists: an umbrella review of clinical outcomes across multiple diseases

This umbrella review synthesizes the evidence for safety and efficacy GLP-1 receptor agonists on multiple outcomes including but not limited to metabolic, cardiovascular and renal outcomes.

Fanjing Kong
Yanru Zhao
Tao Sun
ResearchOpen Access07 Jan 2026
Nature Communications

Volume: 17, P: 1-12
Identification of the cytoplasmic motor–LINC complex involved in rapid chromosome movements during meiotic prophase in Arabidopsis thaliana

The rapid chromosomal movements during meiotic prophase in Arabidopsis thaliana depend on telomere-to-cytoskeleton attachment through the nuclear envelope via a protein complex composed of the kinesin PSS1, the KASH protein SINE3 and the carboxy-terminal SUN-domain proteins.

Bowei Cai
Mariana Tiscareno-Andrade
Mathilde Grelon
Research25 Jul 2025
Nature Plants

Volume: 11, P: 1608-1627
Whole genome re-sequencing in 437 tobacco germplasms identifies plant height candidate genes

Yanru Song
Yuanheng Wang
Long Yang
ResearchOpen Access08 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial

In this multicenter phase 1 trial, treatment with IBI343, a CLDN18.2-targeting antibody–drug conjugate, was safe and showed encouraging clinical responses in patients with advanced gastric or gastroesophageal junction adenocarcinoma.

Jia Liu
Jianwei Yang
Lin Shen
ResearchOpen Access16 Jul 2025
Nature Medicine

Volume: 31, P: 3028-3036
GPRC5A promotes lung colonization of esophageal squamous cell carcinoma

The mechanisms allowing early disseminated cancer cells colonize other tissues remain largely unknown. Here, authors show that GPRC5A axis drives esophageal squamous cell carcinoma lung seeding and metastasis, in a mechanism resembling trophoblast behavior during embryo implantation.

Hongyu Zhou
Licheng Tan
Xin-Yuan Guan
ResearchOpen Access16 Nov 2024
Nature Communications

Volume: 15, P: 1-19
Checklist and analysis of the vascular flora in river valleys of Altay region Xinjiang China

Yanru Zhang
Mingke Zhang
Zhixi Fu
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Complex tsunamigenic near-trench seafloor deformation during the 2011 Tohoku–Oki earthquake

Striking spatial heterogeneity of the shallow rupture behaviour is revealed for the near-trench region in the 2011 Tohoku–Oki earthquake. Significant off-fault deformation is suggested to play a predominant role in near-trench tsunami excitation.

Zhang Kai
Wang Yanru
Wu Ziyin
ResearchOpen Access05 Jun 2023
Nature Communications

Volume: 14, P: 1-10
Dbh⁺ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart

Catecholaminergic transmitters are critical signalling effectors known to be released by sympathetic nerves and adrenomedullary endocrine cells in response to physiological stress. In this paper, the authors demonstrate a uniquely distributed group of catecholaminergic cardiomyocytes with key regulatory roles in cardiac excitation conduction.

Tianyi Sun
Alexander Grassam-Rowe
Ming Lei
ResearchOpen Access28 Nov 2023
Nature Communications

Volume: 14, P: 1-23
Fruquintinib plus paclitaxel versus placebo plus paclitaxel for gastric or gastroesophageal junction adenocarcinoma: the randomized phase 3 FRUTIGA trial

In a randomized, double-blind, placebo-controlled phase 3 trial, the anti-vascular endothelial growth factor receptor small-molecule inhibitor fruquintinib plus chemotherapy significantly extended progression-free survival, but not overall survival, as second-line therapy in patients with advanced gastric or gastroesophageal junction cancers.

Feng Wang
Lin Shen
Rui-Hua Xu
Research01 Jun 2024
Nature Medicine

Volume: 30, P: 2189-2198
ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy

Hui Peng
Yuanqing Li
Tanqi Lou
ResearchOpen Access04 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
A simple monocular depth estimation network for balancing complexity and accuracy

Xuanxuan Liu
Shuai Tang
Yan Wang
ResearchOpen Access15 Apr 2025
Scientific Reports

Volume: 15, P: 1-15
A brain-to-gut signal controls intestinal fat absorption

Neurons in the dorsal motor nucleus of vagus are involved in the absorption of fat in the intestine, and the natural compound puerarin shows utility in modulating this brain–gut axis to reduce fat absorption.

Qianqian Lyu
Wenzhi Xue
Weiqing Wang
Research11 Sept 2024
Nature

Volume: 634, P: 936-943
Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

Gut microbiota play pivotal roles in IBD. Here, Ning et al. use a multi-omics approach to characterize gut microbiota and metabolites alterations, and potential pathogenic bacteria associated with IBD, with the aim to help develop more precise biomarkers for IBD diagnosis and drug targets

Lijun Ning
Yi-Lu Zhou
Jie Hong
ResearchOpen Access06 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice

Although the role of FGFs in cardiovascular disease has attracted extensive attention, the potential role of FGF18 in pathological cardiac hypertrophy remains unknown. Here, the authors show the cardioprotective effect of FGF18 is mediated by maintaining redox homeostasis through FYN/Nox4 signaling.

Gen Chen
Ning An
Xu Wang
ResearchOpen Access04 Mar 2023
Nature Communications

Volume: 14, P: 1-18
The function of PCSK9 in doxorubicin-induced cardiotoxicity and its underlying mechanism

Shuai Shi
Zhihui Qin
Xueqi Li
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-19
High-quality genome assembly and resequencing of modern cotton cultivars provide resources for crop improvement

High-quality genomes of two cultivated tetraploid cottons Gossypium hirsutum cv. NDM8 and Gossypium barbadense acc. Pima90 and resequencing of 1,081 G. hirsutum accessions provide insights into the role of structural variations.

Zhiying Ma
Yan Zhang
Xingfen Wang
ResearchOpen Access09 Aug 2021
Nature Genetics

Volume: 53, P: 1385-1391
Equal parental contribution to the transcriptome is not equal control of embryogenesis

The zygote’s genome is a combination of both the maternal and paternal genomes. Researchers previously found that the maternal and paternal genomes contribute equally to the transcriptome of early plant embryos. However, now Zhao et al. show a strong single parental effect on the development of the basal cell lineage of early proembryos in Arabidopsis.

Peng Zhao
Xuemei Zhou
Meng-xiang Sun
Research26 Oct 2020
Nature Plants

Volume: 6, P: 1354-1364
Immunogenicity, immune persistence, and safety of japanese encephalitis vaccine schedules among adults in Ningxia, China

Dan Wu
Qikai Yin
Yonghua Hu
ResearchOpen Access30 Oct 2025
npj Vaccines

Volume: 10, P: 1-10
Touchless interactive teaching of soft robots through flexible bimodal sensory interfaces

Soft robots are challenging to model and program. Non-specialists face non-negligible obstacles when working with soft robots to perform tasks. Here, the authors propose a method to interactively teach soft robots complex motions through flexible touchless and tactile multimodal sensors.

Wenbo Liu
Youning Duo
Li Wen
ResearchOpen Access26 Aug 2022
Nature Communications

Volume: 13, P: 1-14
Cryptosporidium parvum IId family: clonal population and dispersal from Western Asia to other geographical regions

Rongjun Wang
Longxian Zhang
Lihua Xiao
ResearchOpen Access27 Feb 2014
Scientific Reports

Volume: 4, P: 1-5
Study on the restoration of glass slides dating back to the 1940s

Yuyao Ruan
Yanli Li
Yuhu Li
ResearchOpen Access19 Sept 2024
Heritage Science

Volume: 12, P: 1-13
Adapting crop production to climate change and air pollution at different scales

Elevated CO₂, global warming, ozone pollution and drought are major climate-related environmental challenges affecting field crop production. This Review discusses strategies and opportunities for crop production under climate change and air pollution at the plant, field and ecosystem scales.

Evgenios Agathokleous
Michael Frei
Zhaozhong Feng
Reviews16 Oct 2023
Nature Food

Volume: 4, P: 854-865
A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy

Yanru Zhao
Huaping Li
Dao Wen Wang
ResearchOpen Access09 Jun 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-12
Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure

Dechao Wu
Chongshu Jian
Ling Zhao
ResearchOpen Access12 Mar 2020
Cell Death & Disease

Volume: 11, P: 1-14
A signature based on efferocytosis-related genes for the evaluation of prognosis and the tumour microenvironment in gastric cancer

Lei Wang
Jingjing Ge
Yanru Qin
ResearchOpen Access24 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis

Ziqi Zhu
Yanru Wang
Charlie Degui Chen
Research08 Jun 2010
Cell Research

Volume: 20, P: 794-801
Facilitating integrative and personalized oncology omics analysis with UCSCXenaShiny

UCSCXenaShiny integrates multidimensional data for robust and personalized pan-cancer analysis pipelines, enabling in-depth cancer data exploration in diverse scenarios.

Shensuo Li
Yuzhong Peng
Shixiang Wang
ResearchOpen Access28 Sept 2024
Communications Biology

Volume: 7, P: 1-9
RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability

Tian Zheng
Haoxian Zhou
Yong Zhao
Research03 Jun 2020
Cell Death & Differentiation

Volume: 27, P: 3162-3176
Erratum: PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis

Ziqi Zhu
Yanru Wang
Charlie Degui Chen
Amendments and Corrections02 Aug 2010
Cell Research

Volume: 20, P: 970
Screening of cashmere fineness-related genes and their ceRNA network construction in cashmere goats

Taiyu Hui
Yuanyuan Zheng
Zeying Wang
ResearchOpen Access09 Nov 2021
Scientific Reports

Volume: 11, P: 1-15
lncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca²⁺ overload in myocardial infarction mice model

Lei Jiao
Mengmeng Li
Ying Zhang
ResearchOpen Access09 Dec 2019
Cell Death & Disease

Volume: 10, P: 1-12

Search

Comprehensive evaluation of GLP-1 receptor agonists: an umbrella review of clinical outcomes across multiple diseases

Identification of the cytoplasmic motor–LINC complex involved in rapid chromosome movements during meiotic prophase in Arabidopsis thaliana

Whole genome re-sequencing in 437 tobacco germplasms identifies plant height candidate genes

CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial

GPRC5A promotes lung colonization of esophageal squamous cell carcinoma

Checklist and analysis of the vascular flora in river valleys of Altay region Xinjiang China

Complex tsunamigenic near-trench seafloor deformation during the 2011 Tohoku–Oki earthquake

Dbh⁺ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart

Fruquintinib plus paclitaxel versus placebo plus paclitaxel for gastric or gastroesophageal junction adenocarcinoma: the randomized phase 3 FRUTIGA trial

ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy

A simple monocular depth estimation network for balancing complexity and accuracy

A brain-to-gut signal controls intestinal fat absorption

Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice

The function of PCSK9 in doxorubicin-induced cardiotoxicity and its underlying mechanism

High-quality genome assembly and resequencing of modern cotton cultivars provide resources for crop improvement

Equal parental contribution to the transcriptome is not equal control of embryogenesis

Immunogenicity, immune persistence, and safety of japanese encephalitis vaccine schedules among adults in Ningxia, China

Touchless interactive teaching of soft robots through flexible bimodal sensory interfaces

Cryptosporidium parvum IId family: clonal population and dispersal from Western Asia to other geographical regions

Study on the restoration of glass slides dating back to the 1940s

Adapting crop production to climate change and air pollution at different scales

A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy

Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure

A signature based on efferocytosis-related genes for the evaluation of prognosis and the tumour microenvironment in gastric cancer

PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis

Facilitating integrative and personalized oncology omics analysis with UCSCXenaShiny

RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability

Erratum: PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis

Screening of cashmere fineness-related genes and their ceRNA network construction in cashmere goats

lncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca²⁺ overload in myocardial infarction mice model

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