Terramides A-C are produced by Aspergillus terreus and feature hydroxamic acid motifs in diketopiperazines to chelate iron; however, their biosynthesis is not fully understood. Here, the authors probe the function of two key enzymes TamA and TamB and propose the biosynthesis of terramides A-C as well as their function in the virulence of A. terreus.
- Yi Han
- Yaojie Guo
- Daniel H. Scharf
