Nature Search

Identification of SARS-CoV-2 inhibitors using lung and colonic organoids

The use of lung and colonic organoid systems to assess the susceptibility of lung and gut cells to SARS-CoV-2 and to screen FDA-approved drugs that have antiviral activity against SARS-CoV-2 is demonstrated.

Yuling Han
Xiaohua Duan
Shuibing Chen
Research28 Oct 2020
Nature

Volume: 589, P: 270-275
Author Correction: Identification of SARS-CoV-2 inhibitors using lung and colonic organoids

Yuling Han
Xiaohua Duan
Shuibing Chen
Amendments and Corrections29 May 2024
Nature

Volume: 630, P: E7
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer

A multi-modal analysis of pre-metastatic liver biopsies from patients with localized pancreatic cancer with a minimum of 3 years of follow-up shows that immunological, proliferative and metabolomic features distinguish patients who develop metastases from disease-free survivors and can be used to predict outcomes.

Linda Bojmar
Constantinos P. Zambirinis
David Lyden
Research28 Jun 2024
Nature Medicine

Volume: 30, P: 2170-2180
Cross-disciplinary methodologies for whole-person research – insights from EMPOWER2024

Modern medicine is shifting towards integrative, whole-person research to understand multi-scale complexities of health and disease. However, disciplinary silos, a lack of shared frameworks, and fragmented data hinder progress. The EMPOWER 2024 workshop concluded that the future of whole-person research requires a cultural and methodological shift. This involves embracing interdisciplinarity, sharing ethical data and analysis tools, and educational innovation to translate fragmented data into actionable, holistic health solutions.

Irène Buvat
Erik Aarntzen
Thomas Beyer
News & ViewsOpen Access25 Mar 2026
npj Imaging

Volume: 4, P: 1-8
Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

In space radiation-exposed cells, targeting specific microRNAs with antagomirs can reduce cardiovascular damage and improve cellular function. Here the authors describe a reduction in inflammation and DNA double-strand break activity within these cells upon antagomir treatment.

J. Tyson McDonald
JangKeun Kim
Afshin Beheshti
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-23
Targeted viral adaptation generates a simian-tropic hepatitis B virus that infects marmoset cells

Hepatitis B virus is an almost uniquely human-tropic pathogen for which model systems are scarce. Here, the authors determine key residues within the HBV receptor that form a barrier in the HBV life cycle in primates and identify marmosets as a model candidate for infection with simian-tropic HBV.

Yongzhen Liu
Thomas R. Cafiero
Alexander Ploss
ResearchOpen Access16 Jun 2023
Nature Communications

Volume: 14, P: 1-17
Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

Suparmolecular polymers are built by monomers via non-covalent bonds, whilst the pathway of their nucleation processes is not yet clear. Here, Levin et al.show that the self-assembly of monomers proceeds through a series of metastable states, which are energetically governed by Ostwald’s rule of stages.

Aviad Levin
Thomas O. Mason
Ehud Gazit
Research13 Nov 2014
Nature Communications

Volume: 5, P: 1-8
Formation of functional super-helical assemblies by constrained single heptad repeat

Advances in bionanotechnology demand an increased portfolio of assemblies beyond those currently available. Here, the authors design a crystallographically characterized super-helical sequence composed of single heptad repeats which, through derivatisation, offers vast potential applications.

Sudipta Mondal
Lihi Adler-Abramovich
Ehud Gazit
ResearchOpen Access15 Oct 2015
Nature Communications

Volume: 6, P: 1-8
Active Immunization Against hIAPP Oligomers Ameliorates the Diabetes- Associated Phenotype in a Transgenic Mice Model

Yaron Bram
Sivan Peled
Ehud Gazit
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-6
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

Yang et al. report that HHEX acts as a gatekeeper of pancreatic lineage specification against the liver and duodenum fates via guiding FOXA1, FOXA2 and GATA4 to activate pancreatic genes, while restraining them from activating alternative lineages.

Dapeng Yang
Hyunwoo Cho
Danwei Huangfu
Research04 Jul 2022
Nature Cell Biology

Volume: 24, P: 1064-1076
The spatial landscape of lung pathology during COVID-19 progression

Imaging mass cytometry of the human lung reveals the cellular composition and spatial architecture during COVID-19 and other acute injuries, enabling the characterization of lung pathophysiology from structural, immunological and clinical perspectives.

André F. Rendeiro
Hiranmayi Ravichandran
Robert E. Schwartz
Research29 Mar 2021
Nature

Volume: 593, P: 564-569
A molecular single-cell lung atlas of lethal COVID-19

Lung samples collected soon after death from COVID-19 are used to provide a single-cell atlas of SARS-CoV-2 infection and the ensuing molecular changes.

Johannes C. Melms
Jana Biermann
Benjamin Izar
Research29 Apr 2021
Nature

Volume: 595, P: 114-119
Evolution of antibody immunity to SARS-CoV-2

In a cohort of 87 individuals with COVID-19, the memory B cell response at 6.2 months after the onset of disease evolves in a manner that is consistent with the persistence of SARS-CoV-2 antigen.

Christian Gaebler
Zijun Wang
Michel C. Nussenzweig
Research18 Jan 2021
Nature

Volume: 591, P: 639-644
Author Correction: A molecular single-cell lung atlas of lethal COVID-19

Johannes C. Melms
Jana Biermann
Benjamin Izar
Amendments and Corrections08 Oct 2021
Nature

Volume: 598, P: E2
Peptide-based scaffolds for the culture and maintenance of primary human hepatocytes

Douglas MacPherson
Yaron Bram
Robert E. Schwartz
ResearchOpen Access24 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies

Yaron Bram
Anat Frydman-Marom
Ehud Gazit
ResearchOpen Access04 Mar 2014
Scientific Reports

Volume: 4, P: 1-9
Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation

Sivan Peled
Dorin Sade
Ehud Gazit
ResearchOpen Access28 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy

Jenny C. Jin
Aparna Ananthanarayanan
Melody Y. Zeng
Research19 Aug 2022
Pediatric Research

Volume: 93, P: 1375-1382

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