Nature Search

Correction: Involvement of propionate, citrulline, homoserine, and succinate in oral microbiome metabolite-driven periodontal disease progression

Chikako Ishihara
Misato Sako
Akira Uchiyama
Amendments and CorrectionsOpen Access23 Jan 2026
Scientific Reports

Volume: 16, P: 1-2
Insights into G-protein coupling preference from cryo-EM structures of G_q-bound PTH1R

Description of the cryo-EM structures of the parathyroid hormone type 1 receptor associated with G_q reveals two distinct extracellular conformations with N-glycans stabilizing a ligand-tilted conformation.

Fumiya K. Sano
Kota Shimizume
Osamu Nureki
ResearchOpen Access26 Jun 2025
Nature Chemical Biology

Volume: 21, P: 1906-1914
Single-molecule imaging of EGFR signalling on the surface of living cells

Yasushi Sako
Shigeru Minoghchi
Toshio Yanagida
Research10 Feb 2000
Nature Cell Biology

Volume: 2, P: 168-172
Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome

The 26S proteasome is assembled in several steps, however the extent to which this assembly occurs before or after transport into the nucleus remains unclear. Pack et al.show that full assembly can occur in the cytoplasm, and that a concatameric form of the fully assembled complex is a substrate for nuclear import.

Chan-Gi Pack
Haruka Yukii
Yasushi Saeki
Research06 Mar 2014
Nature Communications

Volume: 5, P: 1-10
Novel Synthesis of Surface-Block Dendrimer Using [4+4] Photocycloaddition of Anthryl Dendrons

Yasushi Yanagimoto
Yutaka Takaguchi
Sadao Tuboi
Reviews26 Oct 2006
Polymer Journal

Volume: 38, P: 1230-1236
Membrane-domain compartmentalization of active GPCRs by β-arrestins through PtdIns(4,5)P₂ binding

A newly identified phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P₂)-binding site reveals multivalent interactions between β-arrestins (βarrs) and PtdIns(4,5)P₂ that facilitate G-protein-coupled receptor (GPCR)–βarr complex formation within specific membrane domains, revealing a mechanism for spatiotemporal control of GPCR signaling.

Ritsuki Kuramoto
Tatsuya Ikuta
Asuka Inoue
ResearchOpen Access06 Aug 2025
Nature Chemical Biology

Volume: 21, P: 1927-1937
Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling

While ERK signalling can produce switch-like cell behaviour, phosphorylation of ERK increases linearly with extracellular signals. Here, the authors solve this seeming contradiction by showing that nuclear translocation of ERK behaves in a switch-like manner and is controlled by ERK activity.

Yuki Shindo
Kazunari Iwamoto
Koichi Takahashi
ResearchOpen Access20 Jan 2016
Nature Communications

Volume: 7, P: 1-10
Origin of the low thermal isomerization rate of rhodopsin chromophore

Masataka Yanagawa
Keiichi Kojima
Yoshinori Shichida
ResearchOpen Access10 Jun 2015
Scientific Reports

Volume: 5, P: 1-9
Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

GPCR kinases (GRKs) phosphorylate active-form G-protein-coupled receptors (GPCRs). Here, the authors reveal that Gq heterotrimer coupled with the angiotensin II type-1 receptor (AT1R) determines the GRK subtypes recruited to the complex in a microdomain, thus defining subsequent AT1R phosphorylation patterns, β-arrestin conformation and functionality.

Kouki Kawakami
Masataka Yanagawa
Asuka Inoue
ResearchOpen Access25 Jan 2022
Nature Communications

Volume: 13, P: 1-16
Automated single-molecule imaging in living cells

Large scale live cell screens often lack single-molecule resolution. Here the authors present an artificial intelligence-assisted TIRF microscope with automated cell searching and focusing, and use it for high-throughput single-molecule imaging of EGFR dynamics in response to various stimuli.

Masato Yasui
Michio Hiroshima
Masahiro Ueda
ResearchOpen Access03 Aug 2018
Nature Communications

Volume: 9, P: 1-11
HIV-1 Gag targeting to the plasma membrane reorganizes sphingomyelin-rich and cholesterol-rich lipid domains

Quantitative microscopies and specific lipid probes revealed that multimerizing HIV-1 Gag in the plasma membrane inner leaflet brings the outer leaflet sphingomyelin-rich and cholesterol-rich lipid domains closer in a curvature-dependent manner.

Nario Tomishige
Maaz Bin Nasim
Toshihide Kobayashi
ResearchOpen Access21 Nov 2023
Nature Communications

Volume: 14, P: 1-18
Visualizing specific protein glycoforms by transmembrane fluorescence resonance energy transfer

A common post-translational modification is the attachment of sugars, but proteins with different sugar chains, known as glycoforms, are hard to distinguish. Here, the authors use transmembrane fluorescence resonance energy transfer to visualize specific glycoforms of the membrane protein GLUT4 in living cells.

Yoshimi Haga
Kumiko Ishii
Tadashi Suzuki
Research19 Jun 2012
Nature Communications

Volume: 3, P: 1-7
The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness

Yue Zhou
Hongli Mao
Yoshihiro Ito
ResearchOpen Access12 Jun 2015
Scientific Reports

Volume: 5, P: 1-13
Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system

Real-time fluorescence imaging analysis with a reconstitution system revealed binding dynamics of Hsp104/Ssa1/Sis1 chaperones to Sup35 amyloid and two distinct modes of amyloid disaggregation, fragmentation and dissolution.

Yoshiko Nakagawa
Howard C.-H. Shen
Motomasa Tanaka
Research17 Feb 2022
Nature Chemical Biology

Volume: 18, P: 321-331
Photo-promoting Fabrication of Silver Nanoparticles in the Presence of Anthracenyl-Focal PAMAM Dendrons

Chisato Hirano
Toyoko Imae
Yutaka Takaguchi
Reviews15 Oct 2006
Polymer Journal

Volume: 38, P: 44-49
Cell cycle dependence of ERK activation dynamics is regulated by PI3K and PAK1 signaling

Ryo Yoshizawa
Yasushi Sako
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-18
Effect of continuous Ia fibre activity suppression on hyperreflexia-related spasticity and maladaptive synaptic connections in the spinal cord after injury

Takuto Hanasaki
Keita Hanaki
Sachiko Lee-Hotta
ResearchOpen Access03 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Involvement of propionate, citrulline, homoserine, and succinate in oral microbiome metabolite-driven periodontal disease progression

Chikako Ishihara
Misato Sako
Akira Uchiyama
ResearchOpen Access28 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Inferring a nonlinear biochemical network model from a heterogeneous single-cell time course data

Yuki Shindo
Yohei Kondo
Yasushi Sako
ResearchOpen Access01 May 2018
Scientific Reports

Volume: 8, P: 1-10
Mutation-Specific Mechanisms of Hyperactivation of Noonan Syndrome SOS Molecules Detected with Single-molecule Imaging in Living Cells

Yuki Nakamura
Nobuhisa Umeki
Yasushi Sako
ResearchOpen Access26 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Insulin signaling shapes fractal scaling of C. elegans behavior

Yukinobu Arata
Itsuki Shiga
Yasushi Sako
ResearchOpen Access21 Jun 2022
Scientific Reports

Volume: 12, P: 1-10
Formation of tubules and helical ribbons by ceramide phosphoethanolamine-containing membranes

Takehiko Inaba
Motohide Murate
Toshihide Kobayashi
ResearchOpen Access09 Apr 2019
Scientific Reports

Volume: 9, P: 1-13
C. elegans episodic swimming is driven by multifractal kinetics

Yusaku Ikeda
Peter Jurica
Yasushi Sako
ResearchOpen Access08 Sept 2020
Scientific Reports

Volume: 10, P: 1-17
Assembly of protein complexes restricts diffusion of Wnt3a proteins

Ritsuko Takada et al. show that Wnt3a assembles into high molecular weight complexes that restrict the diffusion of Wnt within Xenopus embryos. These results suggest that Wnt diffusion in cells is controlled by a balance between higher order complex assembly and dissociation by Wnt-binding proteins.

Ritsuko Takada
Yusuke Mii
Shinji Takada
ResearchOpen Access10 Oct 2018
Communications Biology

Volume: 1, P: 1-14
K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins

Nobuhisa Umeki
Keitaro Shibata
Taro Q. P. Uyeda
ResearchOpen Access29 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
Photosystem II antenna phosphorylation-dependent protein diffusion determined by fluorescence correlation spectroscopy

Masakazu Iwai
Chan-Gi Pack
Akihiko Nakano
ResearchOpen Access03 Oct 2013
Scientific Reports

Volume: 3, P: 1-7
Photoswitchable phospholipid FRET acceptor: Detergent free intermembrane transfer assay of fluorescent lipid analogs

Mariko Sumi
Asami Makino
Toshihide Kobayashi
ResearchOpen Access06 Jun 2017
Scientific Reports

Volume: 7, P: 1-10

Search

Correction: Involvement of propionate, citrulline, homoserine, and succinate in oral microbiome metabolite-driven periodontal disease progression

Insights into G-protein coupling preference from cryo-EM structures of G_q-bound PTH1R

Single-molecule imaging of EGFR signalling on the surface of living cells

Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome

Novel Synthesis of Surface-Block Dendrimer Using [4+4] Photocycloaddition of Anthryl Dendrons

Membrane-domain compartmentalization of active GPCRs by β-arrestins through PtdIns(4,5)P₂ binding

Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling

Origin of the low thermal isomerization rate of rhodopsin chromophore

Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

Automated single-molecule imaging in living cells

HIV-1 Gag targeting to the plasma membrane reorganizes sphingomyelin-rich and cholesterol-rich lipid domains

Visualizing specific protein glycoforms by transmembrane fluorescence resonance energy transfer

The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness

Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system

Photo-promoting Fabrication of Silver Nanoparticles in the Presence of Anthracenyl-Focal PAMAM Dendrons

Cell cycle dependence of ERK activation dynamics is regulated by PI3K and PAK1 signaling

Effect of continuous Ia fibre activity suppression on hyperreflexia-related spasticity and maladaptive synaptic connections in the spinal cord after injury

Involvement of propionate, citrulline, homoserine, and succinate in oral microbiome metabolite-driven periodontal disease progression

Inferring a nonlinear biochemical network model from a heterogeneous single-cell time course data

Mutation-Specific Mechanisms of Hyperactivation of Noonan Syndrome SOS Molecules Detected with Single-molecule Imaging in Living Cells

Insulin signaling shapes fractal scaling of C. elegans behavior

Formation of tubules and helical ribbons by ceramide phosphoethanolamine-containing membranes

C. elegans episodic swimming is driven by multifractal kinetics

Assembly of protein complexes restricts diffusion of Wnt3a proteins

K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins

Photosystem II antenna phosphorylation-dependent protein diffusion determined by fluorescence correlation spectroscopy

Photoswitchable phospholipid FRET acceptor: Detergent free intermembrane transfer assay of fluorescent lipid analogs

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