Nature Search

Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer

Multi-region sequencing of small cell lung cancers (SCLC) can improve our understanding of the disease. Here the authors analyse 120 multi-region samples from 40 SCLC patients with whole exome sequencing and characterise their mutational burden, evolution, heterogeneity, and potential prognostic biomarkers.

Huaqiang Zhou
Yi Hu
Ningning Zhou
ResearchOpen Access14 Sept 2021
Nature Communications

Volume: 12, P: 1-11
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response

Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis.

Jianhui Sun
Jun Yang
Gan Wang
ResearchOpen Access15 Sept 2025
Nature Immunology

Volume: 26, P: 1660-1672
Initially anode-free sodium metal battery enabled by strain-engineered single-crystal aluminum substrate with (100)-preferred orientation

Initially anode-free design can obtain the maximum energy density of sodium metal batteries. Here, authors construct a highly ordered and regularly arranged Al(100) single crystal current collector, achieving uniform reversible sodium deposition capability and long cycle performance.

Fang Tang
Yang Yang
Yan Yu
ResearchOpen Access07 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Radiotherapy is recommended for hormone receptor-negative older breast cancer patients after breast conserving surgery

Yaxiong Liu
Jinsong Li
Jinsheng Zeng
ResearchOpen Access12 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients

Yaxiong Liu
Honghui Li
Qiuhong Tian
ResearchOpen Access17 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma

The rare lung cancer subtype pulmonary lymphoepithelioma-like carcinoma is linked to Epstein-Barr virus infection. Here, the authors provide a mutational landscape for this cancer, showing a low burden of somatic mutations and high prevalence of copy number variations.

Shaodong Hong
Dongbing Liu
Li Zhang
ResearchOpen Access16 Jul 2019
Nature Communications

Volume: 10, P: 1-12
Experimentally validated design principles of heteroatom-doped-graphene-supported calcium single-atom materials for non-dissociative chemisorption solid-state hydrogen storage

Via the first-principles calculations and experimental verifications, a guiding principle is established to design heteroatom-doped-graphene-supported Ca single-atom carbon nanomaterials for efficient non-dissociative solid-state hydrogen storage.

Yong Gao
Zhenglong Li
Hongge Pan
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-14
Investigating the causal associations between metabolic biomarkers and the risk of kidney cancer

A multiple Mendelian randomization study emphasizes the central role of lactate in kidney tumorigenesis and provides novel insights into possible mechanism how phospholipids could affect kidney tumorigenesis.

Lede Lin
Yaxiong Tang
Xu Hu
ResearchOpen Access01 Apr 2024
Communications Biology

Volume: 7, P: 1-7
Surufatinib plus toripalimab combined with etoposide and cisplatin as first-line treatment in advanced small-cell lung cancer patients: a phase Ib/II trial

Yaxiong Zhang
Yan Huang
Wenfeng Fang
ResearchOpen Access27 Sept 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-8
(−)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo

Yuwen Chen
Wenhua Li
Yaxiong Tang
ResearchOpen Access11 Jun 2018
Scientific Reports

Volume: 8, P: 1-11
Cytosolic peptides encoding Ca_V1 C-termini downregulate the calcium channel activity-neuritogenesis coupling

When present in the cytosol, a variety of peptides encoded by the distal carboxyl-termini of the L-type Ca_V1 calcium channels downregulate channel activity and neurite outgrowth.

Yaxiong Yang
Zhen Yu
Xiaodong Liu
ResearchOpen Access19 May 2022
Communications Biology

Volume: 5, P: 1-18
PBRM1 mutation and preliminary response to immune checkpoint blockade treatment in non-small cell lung cancer

Huaqiang Zhou
Jiaqing Liu
Li Zhang
ResearchOpen Access16 Mar 2020
npj Precision Oncology

Volume: 4, P: 1-4
hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model

Huiming Xu
Wei Jiang
Changyong Tang
ResearchOpen Access20 Jan 2024
npj Regenerative Medicine

Volume: 9, P: 1-16
Publisher Correction: Inheritance patterns of the transcriptome in hybrid chickens and their parents revealed by expression analysis

Hongchang Gu
Xin Qi
Lujiang Qu
Amendments and CorrectionsOpen Access17 Apr 2020
Scientific Reports

Volume: 10, P: 1-5
QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study

Yan Huang
Yunpeng Yang
Wenfeng Fang
ResearchOpen Access29 Jan 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-10
Transferrin plays a central role in coagulation balance by interacting with clotting factors

Xiaopeng Tang
Zhiye Zhang
Ren Lai
ResearchOpen Access06 Dec 2019
Cell Research

Volume: 30, P: 119-132
Interactive residual coordinate attention and contrastive learning for infrared and visible image fusion in triple frequency bands

Zhihua Xie
Sha Zong
Guodong Liu
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-16
Inheritance patterns of the transcriptome in hybrid chickens and their parents revealed by expression analysis

Hongchang Gu
Xin Qi
Lujiang Qu
ResearchOpen Access08 Apr 2019
Scientific Reports

Volume: 9, P: 1-10
Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation

Cheng Xu
Yunfei Wang
Ren Lai
Research24 Oct 2018
Oncogene

Volume: 38, P: 1832-1844
Structural identification of riluzole-binding site on human TRPC5

Yaxiong Yang
Miao Wei
Lei Chen
CorrespondenceOpen Access12 Jul 2022
Cell Discovery

Volume: 8, P: 1-5
Cationic nanocarriers induce cell necrosis through impairment of Na⁺/K⁺-ATPase and cause subsequent inflammatory response

Xiawei Wei
Bin Shao
Zhirong Zhang
ResearchOpen Access23 Jan 2015
Cell Research

Volume: 25, P: 237-253

Search

Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer

Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response

Initially anode-free sodium metal battery enabled by strain-engineered single-crystal aluminum substrate with (100)-preferred orientation

Radiotherapy is recommended for hormone receptor-negative older breast cancer patients after breast conserving surgery

Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients

The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma

Experimentally validated design principles of heteroatom-doped-graphene-supported calcium single-atom materials for non-dissociative chemisorption solid-state hydrogen storage

Investigating the causal associations between metabolic biomarkers and the risk of kidney cancer

Surufatinib plus toripalimab combined with etoposide and cisplatin as first-line treatment in advanced small-cell lung cancer patients: a phase Ib/II trial

(−)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo

Cytosolic peptides encoding Ca_V1 C-termini downregulate the calcium channel activity-neuritogenesis coupling

PBRM1 mutation and preliminary response to immune checkpoint blockade treatment in non-small cell lung cancer

hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model

Publisher Correction: Inheritance patterns of the transcriptome in hybrid chickens and their parents revealed by expression analysis

QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study

Transferrin plays a central role in coagulation balance by interacting with clotting factors

Interactive residual coordinate attention and contrastive learning for infrared and visible image fusion in triple frequency bands

Inheritance patterns of the transcriptome in hybrid chickens and their parents revealed by expression analysis

Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation

Structural identification of riluzole-binding site on human TRPC5

Cationic nanocarriers induce cell necrosis through impairment of Na⁺/K⁺-ATPase and cause subsequent inflammatory response

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