The pathological mechanisms underlying multiple system atrophy (MSA) remain unclear. Here, the authors show in mouse and human MSA models that α-synuclein spreads from neurons to oligodendrocytes via TLR2 leading to myelination defects, and that blocking TLR2 prevents glial cytoplasmic inclusions and myelin damage.
- Eun-Jin Bae
- Sangwoo Ham
- Seung-Jae Lee
