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Reinvigorating COTL1^high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours

You, Hu et al. discover a population of COTL1^high NK cells regulated by GITRL⁺ macrophages and demonstrate their functional importance in mediating anti-tumour immunity in cancer with impaired tumour-specific MHC-I expression.

Wenhua You
Chupeng Hu
Yun Chen
ResearchOpen Access30 Mar 2026
Nature Cell Biology

P: 1-15
Unified multimodal multidomain polymer representation for property prediction

Qi Huang
Yedi Li
Wenjie Yu
ResearchOpen Access26 May 2025
npj Computational Materials

Volume: 11, P: 1-11

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Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours

Unified multimodal multidomain polymer representation for property prediction

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Reinvigorating COTL1^high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours