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Multigenerational proteolytic inactivation of restriction upon subtle genomic hypomethylation in Pseudomonas aeruginosa

Elevated temperatures inactivate a type I restriction endonuclease in P. aeruginosa for ~60 generations via proteolytic degradation triggered by DNA hypomodification, preventing self-targeting and enabling recovery of restriction activity.

Esther Shmidov
Alexis Villani
Ehud Banin
Research08 Sept 2025
Nature Microbiology

Volume: 10, P: 2498-2510
Marriage of black phosphorus and Cu²⁺ as effective photothermal agents for PET-guided combination cancer therapy

A balance between high stability and rapid degradation is required for effective photothermal anti-cancer agents. Here, the authors use Cu²⁺ to accelerate the degradation of black phosphorus nanosheets while enhancing its photothermal ability and apply this material for PET-guided, CDT-enhanced combination cancer therapy in mice.

Kuan Hu
Lin Xie
Ming-Rong Zhang
ResearchOpen Access08 Jun 2020
Nature Communications

Volume: 11, P: 1-15
Uncovering hidden factors of cognitive resilience in Alzheimer’s disease using a conditional-Gaussian mixture variational autoencoder

Yiding Cao
Yogya Chukkapalli
Catherine C. Kaczorowski
ResearchOpen Access25 Nov 2025
npj Dementia

Volume: 1, P: 1-14
Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment

Targeted black phosphorus nanosheet-based therapeutics that efficiently deliver resolvin D1 to lesional macrophages for the treatment of atherosclerosis by reducing oxidative stress and resolving inflammation have been discussed.

Zhongshan He
Wei Chen
Wei Tao
Research19 Jun 2024
Nature Nanotechnology

Volume: 19, P: 1386-1398
Transition state structure detection with machine learningś

Yitao Si
Yiding Ma
Maochang Liu
ResearchOpen Access01 Jul 2025
npj Computational Materials

Volume: 11, P: 1-10
Functional assessment of missense variants of uncertain significance in the cancer susceptibility gene PALB2

Shijie Wu
Lina Qi
Yiding Chen
ResearchOpen Access19 Jul 2022
npj Breast Cancer

Volume: 8, P: 1-11
Exploration of linear and interpretable models for quantification of cell parameters via contactless short-wave infrared hyperspectral sensing

Anjana Hevaganinge
Eva Lowenstein
Yang Tao
ResearchOpen Access17 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Analysis of audiological outcomes of children referred from a universal newborn hearing screening program over 9 years in Beijing, China

Yue Li
Xiaozhe Yang
Lihui Huang
ResearchOpen Access19 Dec 2023
Scientific Reports

Volume: 13, P: 1-11
Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment

Weinian Liao
Chaonan Liu
Junping Wang
Research30 Aug 2023
Cellular & Molecular Immunology

Volume: 20, P: 1216-1231
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis

Wei Su
Yingying Guo
Haihai Liang
ResearchOpen Access01 Jul 2024
Experimental & Molecular Medicine

Volume: 56, P: 1643-1654
Genome-wide screening in the haploid system reveals Slc25a43 as a target gene of oxidative toxicity

Jinxin Zhang
Yiding Zhao
Ling Shuai
ResearchOpen Access30 Mar 2022
Cell Death & Disease

Volume: 13, P: 1-11
A first-in-human phase 1 study of nofazinlimab, an anti-PD-1 antibody, in advanced solid tumors and in combination with regorafenib in metastatic colorectal cancer

Daphne Day
John J. Park
Archie N. Tse
ResearchOpen Access20 Sept 2023
British Journal of Cancer

Volume: 129, P: 1608-1618
Development of 1-N-¹¹C-Methyl-l- and -d-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan

Lin Xie
Jun Maeda
Ming-Rong Zhang
ResearchOpen Access10 Nov 2015
Scientific Reports

Volume: 5, P: 1-9
A novel monoacylglycerol lipase-targeted ¹⁸F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network

Ran Cheng
Masayuki Fujinaga
Steven H. Liang
Research05 May 2022
Acta Pharmacologica Sinica

Volume: 43, P: 3002-3010
Nanomeshed Si nanomembranes

Xun Han
Kyung Jin Seo
Hui Fang
ResearchOpen Access03 May 2019
npj Flexible Electronics

Volume: 3, P: 1-8
Correlation between social proximity and mobility similarity

Chao Fan
Yiding Liu
Tao Zhou
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model

Kexin Chen
Silan Shen
Hu Zhang
ResearchOpen Access07 Sept 2022
Scientific Data

Volume: 9, P: 1-13

Search

Multigenerational proteolytic inactivation of restriction upon subtle genomic hypomethylation in Pseudomonas aeruginosa

Marriage of black phosphorus and Cu²⁺ as effective photothermal agents for PET-guided combination cancer therapy

Uncovering hidden factors of cognitive resilience in Alzheimer’s disease using a conditional-Gaussian mixture variational autoencoder

Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment

Transition state structure detection with machine learningś

Functional assessment of missense variants of uncertain significance in the cancer susceptibility gene PALB2

Exploration of linear and interpretable models for quantification of cell parameters via contactless short-wave infrared hyperspectral sensing

Analysis of audiological outcomes of children referred from a universal newborn hearing screening program over 9 years in Beijing, China

Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment

YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis

Genome-wide screening in the haploid system reveals Slc25a43 as a target gene of oxidative toxicity

A first-in-human phase 1 study of nofazinlimab, an anti-PD-1 antibody, in advanced solid tumors and in combination with regorafenib in metastatic colorectal cancer

Development of 1-N-¹¹C-Methyl-l- and -d-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan

A novel monoacylglycerol lipase-targeted ¹⁸F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network

Nanomeshed Si nanomembranes

Correlation between social proximity and mobility similarity

A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model

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