Nature Search

Biomimetic fractal topography enhances podocyte maturation in vitro

Liu and colleagues demonstrate that biomimetic fractal patterns derived from glomerular histology can enhance the maturation of podocytes (highly differentiated glomerular cells) that are grown in culture. This work presents a bioengineered platform for improved cell culture fidelity.

Chuan Liu
Praful Aggarwal
Milica Radisic
ResearchOpen Access15 Dec 2025
Nature Communications

Volume: 16, P: 1-20
Stretchable ultrasonic arrays for the three-dimensional mapping of the modulus of deep tissue

A stretchable ultrasonic array conforming to the skin allows for the three-dimensional imaging of tissue modulus at depths of up to 4 cm.

Hongjie Hu
Yuxiang Ma
Sheng Xu
Research01 May 2023
Nature Biomedical Engineering

Volume: 7, P: 1321-1334
Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways

Hamidzada et al. show that human pluripotent stem cell–derived macrophages are educated into a tissue-resident fate within human cardiac microtissues, enhancing its function via efferocytic ingestion of stressed cardiomyocyte cargo.

Homaira Hamidzada
Simon Pascual-Gil
Slava Epelman
Research07 May 2024
Nature Cardiovascular Research

Volume: 3, P: 567-593
A multi-organ chip with matured tissue niches linked by vascular flow

Tissue chips with matured human heart, liver, bone and skin tissue niches linked by recirculating vascular flow recapitulate interdependent functions of these organs.

Kacey Ronaldson-Bouchard
Diogo Teles
Gordana Vunjak-Novakovic
Research27 Apr 2022
Nature Biomedical Engineering

Volume: 6, P: 351-371
Three-dimensional transistor arrays for intra- and inter-cellular recording

A three-dimensional field-effect transistor array produced via compressive buckling enables accurate and minimally invasive intra- and intercellular recordings in cells and cellular networks.

Yue Gu
Chunfeng Wang
Sheng Xu
Research23 Dec 2021
Nature Nanotechnology

Volume: 17, P: 292-300
Mapping signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources

An integrative strategy based on mass spectrometry for the phosphoproteomic profiling of normal and fibrotic cardiac tissue from diverse sources identifies key signalling pathways involved in cardiac fibrosis.

Uros Kuzmanov
Erika Yan Wang
Andrew Emili
Research13 Jul 2020
Nature Biomedical Engineering

Volume: 4, P: 889-900
Integrating organoids and organ-on-a-chip devices

Organoids and organs-on-chips aim to improve drug testing and disease modelling, but each has limitations. This Review discusses the integration of these systems to improve cellular hierarchy, structural fidelity, reproducibility, throughput, scale-up and efficiency to improve translational outcomes.

Yimu Zhao
Shira Landau
Milica Radisic
Reviews02 Jul 2024
Nature Reviews Bioengineering

Volume: 2, P: 588-608
A wearable cardiac ultrasound imager

Innovations in device design, material fabrication and deep learning are described, leading to a wearable ultrasound transducer capable of dynamic cardiac imaging in various environments and under different conditions.

Hongjie Hu
Hao Huang
Sheng Xu
ResearchOpen Access25 Jan 2023
Nature

Volume: 613, P: 667-675
A framework for developing sex-specific engineered heart models

Sex-related differences in health and disease are often overlooked in tissue engineering. This Review discusses sex-based differences in the (patho)physiology of the cardiovascular system, providing a design framework for sex-specific cardiac tissue models and an outlook to developing sex-specific in vitro models in general.

Roberta Lock
Hadel Al Asafen
Gordana Vunjak-Novakovic
Reviews20 Oct 2021
Nature Reviews Materials

Volume: 7, P: 295-313
Kinase inhibitor screening using artificial neural networks and engineered cardiac biowires

Genevieve Conant
Samad Ahadian
Milica Radisic
ResearchOpen Access18 Sept 2017
Scientific Reports

Volume: 7, P: 1-12

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