Zhou et al. reveal that rhein improves adipose tissue thermogenesis via suppressing the NLRP3 inflammasome in macrophages during obesity. They further identify that rhein directly binds to SIRT2 and inhibits NLRP3 inflammasome by activating SIRT2.
- Ruo-Nan Zhou
- Zi-Wei Zhu
- Wen-Bin Shang