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Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans

Li et al. identify a human TCF1-expressing stem-like T cell population that is associated with immune-mediated pathogenesis in ulcerative colitis.

Yingcong Li
Ciro Ramírez-Suástegui
Pandurangan Vijayanand
Research19 Jun 2024
Nature Immunology

Volume: 25, P: 1231-1244
Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function

Prior studies implicate an allele near laccase domain containing 1 (LACC1) for risk of Crohn’s disease and decreased LACC1 expression in T cells. Using human genome analyzes and mouse genetic models, here the authors link specific LACC1 variants with the modulation of T cell gene expression, metabolism and function.

Yingcong Li
Gabriel Ascui
Mitchell Kronenberg
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

A study using a mouse solid tumour model suggests that adjusting the dosing frequency of the PI3Kδ inhibitor AMG319 in the treatment of human cancers could decrease tumour growth with fewer adverse effects.

Simon Eschweiler
Ciro Ramírez-Suástegui
Christian H. Ottensmeier
ResearchOpen Access04 May 2022
Nature

Volume: 605, P: 741-746
Constructing a nomogram for short-term prognosis in postoperative patients with aneurysmal subarachnoid hemorrhage: a two-center retrospective study

Yingcong Wei
Xiaoyong Lin
Gang Zhu
ResearchOpen Access01 Aug 2025
Scientific Reports

Volume: 15, P: 1-20
Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma

Li Xu
Yingcong Wang
Jumei Shi
Research08 May 2023
Leukemia

Volume: 37, P: 1576-1579
Nomogram model for decompressing craniectomy after mechanical thrombectomy in patients with acute ischemic stroke

Yingcong Wei
Jing Xiao
Gang Zhu
ResearchOpen Access21 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
KDM4B enhances immune surveillance via demethylating cGAS

Qiao Peng
Huimin Zhuo
Meiling Lu
ResearchOpen Access01 Jul 2025
Cell Death & Disease

Volume: 16, P: 1-13
Drivers of spatio-temporal changes in paddy soil pH in Jiangxi Province, China from 1980 to 2010

Xi Guo
Hongyi Li
Asim Biswas
ResearchOpen Access09 Feb 2018
Scientific Reports

Volume: 8, P: 1-11
A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway

Kang Lu
Bo Li
Jumei Shi
ResearchOpen Access01 Apr 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-11
Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson’s Disease

Rutong Ren
Chunyan Shi
Hongbin Han
ResearchOpen Access24 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
DCZ3301, a novel cytotoxic agent, inhibits proliferation in diffuse large B-cell lymphoma via the STAT3 pathway

Xi Sun
Bo Li
Weiliang Zhu
ResearchOpen Access12 Oct 2017
Cell Death & Disease

Volume: 8, P: e3111
FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation

Rui Wang
Yan Wang
Ping Wang
Research19 Mar 2013
Cell Research

Volume: 23, P: 803-819

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Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans

Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

Constructing a nomogram for short-term prognosis in postoperative patients with aneurysmal subarachnoid hemorrhage: a two-center retrospective study

Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma

Nomogram model for decompressing craniectomy after mechanical thrombectomy in patients with acute ischemic stroke

KDM4B enhances immune surveillance via demethylating cGAS

Drivers of spatio-temporal changes in paddy soil pH in Jiangxi Province, China from 1980 to 2010

A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway

Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson’s Disease

DCZ3301, a novel cytotoxic agent, inhibits proliferation in diffuse large B-cell lymphoma via the STAT3 pathway

FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation

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