Nature Search

Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex

Here, the authors employed 19 F NMR and Gaussian accelerated MD simulations to determine the conformational landscape of the adenosine-A2A receptor and mini-Gαsβγ complex, enabling determination of an intermediate structure of the complex with cryoEM.

Maxine Bi
Xudong Wang
Libin Ye
ResearchOpen Access28 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Hydrogen sulfide drives horizontal transfer of plasmid-borne antibiotic resistance genes in wastewater ecosystems

This study shows the role of hydrogen sulfide as a driver of plasmid-mediated horizontal gene transfer of antimicrobial resistance genes.

Haining Huang
Lin Lin
Yinguang Chen
Research07 Nov 2025
Nature Water

Volume: 3, P: 1268-1280
Predicting water-conducting fracture zone height in three-soft coal seams using a BOA-MLP model

Zheng Tang
Haochen Tong
Ziquan Wu
ResearchOpen Access03 Jan 2026
Scientific Reports

Volume: 16, P: 1-19
A high-quality chromosome-level reference genome of Pulsatilla chinensis

Ting Wang
Chenhao Zhang
Xiaoming Song
ResearchOpen Access24 Dec 2025
Scientific Data

P: 1-9
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase

Here the authors show the structures of single-pass transmembrane receptor guanylyl cyclase in both apo and hormone-bound states, advancing our understanding of cross-membrane signaling by single-pass transmembrane receptors.

Shian Liu
Alexander M. Payne
Xin-Yun Huang
Research14 Nov 2024
Nature Structural & Molecular Biology

Volume: 32, P: 469-478
Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging

The applications of organic small-molecule contrast agents for multispectral optoacoustic imaging have been restrained by several challenges including relatively low extinction coefficient, poor water solubility and weak optoacoustic performance. Here, the authors address these limitations by constructing water-dispersible supramolecular optoacoustic assemblies based on cucurbit[8]uril.

Yinglong Wu
Lihe Sun
Yanli Zhao
ResearchOpen Access03 Jul 2023
Nature Communications

Volume: 14, P: 1-17
Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials

Chao Lin
Hongquan He
Ning Liu
ResearchOpen Access25 Aug 2015
Scientific Reports

Volume: 5, P: 1-7
Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy

Prussian blue has been used as a photothermal agent for cancer therapy. Here the authors describe the production of Prussian blue nanoparticles from S. oneidensis MR-1 bacteria and show that a Prussian blue-based mitochondria-targeting nanoplatform potentiates response to immune checkpoint blockade.

Dongdong Wang
Jiawei Liu
Yanli Zhao
ResearchOpen Access23 May 2023
Nature Communications

Volume: 14, P: 1-16
Unveiling the role of the extracellular matrix in the osteosarcoma tumor microenvironment through integrated transcriptomics and experimental validation

Yuyang Liu
Yuchen Han
Jianxiong Li
Research07 Oct 2025
Cancer Gene Therapy

Volume: 32, P: 1370-1384
Crystal OH mediating pathway for hydrogen peroxide production via two-electron water oxidation in non-carbonate electrolytes

Two-electron water oxidation is an important strategy to generate H2O2 but it often requires carbonate electrolyte that will often limit its further application. Cu₂(OH)₂CO₃ tablet electrode is found to be able to efficiently produce hydrogen peroxide in noncarbonate electrolyte by a crystal OH mediating pathway.

Ruilin Wang
Hao Luo
Zhuofeng Hu
ResearchOpen Access02 Dec 2024
Nature Communications

Volume: 15, P: 1-12
Petal size is controlled by the MYB73/TPL/HDA19-miR159-CKX6 module regulating cytokinin catabolism in Rosa hybrida

Expression of MIR159 is attenuated by a MYB73/TPL/HDA19 repression complex during rose petal development. Reduced MIR159 levels lead to accumulation of Cytokinin Oxidase 6, causing cytokinin clearance and subsequent arrest of cell division.

Weikun Jing
Feifei Gong
Nan Ma
ResearchOpen Access04 Nov 2023
Nature Communications

Volume: 14, P: 1-18
Dual-responsive bis-Schiff base fluorescent probe for simultaneous detection of Zn²⁺ and HClO in environmental monitoring and information encryption

Fan Yang
Yinglong Ma
Jing Huang
ResearchOpen Access28 Nov 2025
Scientific Reports

Volume: 15, P: 1-11
Structures of β₁-adrenergic receptor in complex with Gs and ligands of different efficacies

Su et al. report cryo-EM structures of β₁-adrenergic receptor, Gs and ligands of different efficacies. These complexes have similar overall architecture, but with local conformational differences and different stabilities.

Minfei Su
Navid Paknejad
Xin-Yun Huang
ResearchOpen Access14 Jul 2022
Nature Communications

Volume: 13, P: 1-13
CXCR4-targeted near-infrared imaging allows detection of orthotopic and metastatic human osteosarcoma in a mouse model

Guofeng Guan
Yao Lu
Yong Zhou
ResearchOpen Access16 Oct 2015
Scientific Reports

Volume: 5, P: 1-9
Increased pulse wave transit time after percutaneous coronary intervention procedure in CAD patients

Lizhen Ji
Chengyu Liu
Yinglong Hou
ResearchOpen Access08 Jan 2018
Scientific Reports

Volume: 8, P: 1-7
Improvement of multiple agronomic traits by a disease resistance gene via cell wall reinforcement

The rice resistance gene Xa4, which protects rice against Xanthomonas oryzae pv. oryzae, is widely used in global rice production. Now, a study reveals that Xa4 encodes a cell-wall-associated kinase that improves multiple agronomic traits by regulating cell wall strength.

Keming Hu
Jianbo Cao
Shiping Wang
Research17 Feb 2017
Nature Plants

Volume: 3, P: 1-9
Lab-scale design of two layers wood cellulose filter media to maximize life span for intake air filtration

Qian Yang
Guodong Zhao
Zhong Liu
ResearchOpen Access04 Feb 2021
Scientific Reports

Volume: 11, P: 1-7
Antihypertensive treatment effect of two dual therapies according to sodium sensitivity

Qi-Fang Huang
Di Zhang
Jianqiang Xiao
Research06 Oct 2025
Hypertension Research

Volume: 49, P: 340-349
Automated segmentation of brain metastases in magnetic resonance imaging using deep learning in radiotherapy

Ruiping Zhang
Yinglong Liu
Peng Peng
ResearchOpen Access25 Sept 2025
Scientific Reports

Volume: 15, P: 1-11
Computational assessment of blood lipid influence on hemodynamics in human retinal vessels

Yu Ding
Zhengxuan Jiang
Liming Tao
ResearchOpen Access13 May 2025
Scientific Reports

Volume: 15, P: 1-14
Self-seeding circulating tumor cells promote the proliferation and metastasis of human osteosarcoma by upregulating interleukin-8

Tao Liu
Qiong Ma
Xiuchun Qiu
ResearchOpen Access31 Jul 2019
Cell Death & Disease

Volume: 10, P: 1-13
Transcriptome-wide analysis of chromium-stress responsive microRNAs to explore miRNA-mediated regulatory networks in radish (Raphanus sativus L.)

Wei Liu
Liang Xu
Liwang Liu
ResearchOpen Access11 Sept 2015
Scientific Reports

Volume: 5, P: 1-17
A large-scale multi-label 12-lead electrocardiogram database with standardized diagnostic statements

Liu Hui
Chen Dan
Wang Yinglong
ResearchOpen Access07 Jun 2022
Scientific Data

Volume: 9, P: 1-9
Comparative proteomic analysis provides insight into a complex regulatory network of taproot formation in radish (Raphanus sativus L.)

Yang Xie
Liang Xu
Liwang Liu
ResearchOpen Access01 Oct 2018
Horticulture Research

Volume: 5, P: 1-14
Interactive effects of drought and heat stresses on morpho-physiological attributes, yield, nutrient uptake and oxidative status in maize hybrids

Hafiz Athar Hussain
Shengnan Men
Longchang Wang
ResearchOpen Access07 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
PBK correlates with prognosis, immune escape and drug response in LUAD

Hongyu Ma
Jing Zhang
Chaoqun Lian
ResearchOpen Access22 Nov 2023
Scientific Reports

Volume: 13, P: 1-16
Alteration of intracellular protein expressions as a key mechanism of the deterioration of bacterial denitrification caused by copper oxide nanoparticles

Yinglong Su
Xiong Zheng
Kun Liu
ResearchOpen Access28 Oct 2015
Scientific Reports

Volume: 5, P: 1-11

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Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex

Hydrogen sulfide drives horizontal transfer of plasmid-borne antibiotic resistance genes in wastewater ecosystems

Predicting water-conducting fracture zone height in three-soft coal seams using a BOA-MLP model

A high-quality chromosome-level reference genome of Pulsatilla chinensis

Architecture and activation of single-pass transmembrane receptor guanylyl cyclase

Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging

Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials

Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy

Unveiling the role of the extracellular matrix in the osteosarcoma tumor microenvironment through integrated transcriptomics and experimental validation

Crystal OH mediating pathway for hydrogen peroxide production via two-electron water oxidation in non-carbonate electrolytes

Petal size is controlled by the MYB73/TPL/HDA19-miR159-CKX6 module regulating cytokinin catabolism in Rosa hybrida

Dual-responsive bis-Schiff base fluorescent probe for simultaneous detection of Zn²⁺ and HClO in environmental monitoring and information encryption

Structures of β₁-adrenergic receptor in complex with Gs and ligands of different efficacies

CXCR4-targeted near-infrared imaging allows detection of orthotopic and metastatic human osteosarcoma in a mouse model

Increased pulse wave transit time after percutaneous coronary intervention procedure in CAD patients

Improvement of multiple agronomic traits by a disease resistance gene via cell wall reinforcement

Lab-scale design of two layers wood cellulose filter media to maximize life span for intake air filtration

Antihypertensive treatment effect of two dual therapies according to sodium sensitivity

Automated segmentation of brain metastases in magnetic resonance imaging using deep learning in radiotherapy

Computational assessment of blood lipid influence on hemodynamics in human retinal vessels

Self-seeding circulating tumor cells promote the proliferation and metastasis of human osteosarcoma by upregulating interleukin-8

Transcriptome-wide analysis of chromium-stress responsive microRNAs to explore miRNA-mediated regulatory networks in radish (Raphanus sativus L.)

A large-scale multi-label 12-lead electrocardiogram database with standardized diagnostic statements

Comparative proteomic analysis provides insight into a complex regulatory network of taproot formation in radish (Raphanus sativus L.)

Interactive effects of drought and heat stresses on morpho-physiological attributes, yield, nutrient uptake and oxidative status in maize hybrids

PBK correlates with prognosis, immune escape and drug response in LUAD

Alteration of intracellular protein expressions as a key mechanism of the deterioration of bacterial denitrification caused by copper oxide nanoparticles

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