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Showing 1–2 of 2 results
Advanced filters: Author: Yingquan Qin Clear advanced filters

  • Here the authors use genetic mutations to alter TCR signal strength and clonal selection of exhausted CD8+ T cells. They implicate CARD11 signaling as a sensor of this TCR signal strength and as a regulator of antitumor function in exhausted T cells that might be targeted to enhance cancer immunotherapies.

    • Yu Hu
    • Qifan Zhao
    • Wei Lu
    Research
    Nature Immunology
    Volume: 26, P: 1113-1126