Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Yinwen Zhang Clear advanced filters

  • Drug combination discovery remains slow and challenging. Here, the authors introduce Combocat, an open-source framework that combines acoustic liquid handling protocols with machine learning to achieve ultrahigh-throughput drug combination screening; as proof of concept, they use Combocat to screen 9,045 drug combinations in a neuroblastoma cell line.

    • William C. Wright
    • Min Pan
    • Paul Geeleher
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Mistakes in the maintenance of CG methylation are a source of heritable epimutations in plants. This study systematically identifies and characterizes epimutation hotspots along the Arabidopsis genome and dissects their molecular properties.

    • Rashmi R. Hazarika
    • Michele Serra
    • Frank Johannes
    Research
    Nature Plants
    Volume: 8, P: 146-156

  • The genome of the model fern species Ceratopteris richardii reveals a history of remarkably dynamic genome evolution, including rapid changes in genome content and structure following the most recent whole-genome duplication approximately 60 million years ago.

    • D. Blaine Marchant
    • Guang Chen
    • Zhong-Hua Chen
    ResearchOpen Access
    Nature Plants
    Volume: 8, P: 1038-1051

  • Long-chain alcohols synthesis from syngas conversion is a promising route for the production of high-value chemicals. Here the authors show that a heterogeneous Fe5C2/Cu catalyst derived from layered double hydroxides precursor exhibits excellent performance with a space time yield of 0.101 g gcat−1 h−1 at a low pressure of 1 MPa.

    • Yinwen Li
    • Wa Gao
    • Ding Ma
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • The molecular origins of epialleles remain unknown. Here, the authors show that a positive feedback loop between H3K9me2 and CMT2/3 is a major contributing factor to the origins of spontaneous epialleles and that heterochromatin is a quantitative trait associated with spontaneous epiallele formation.

    • Yinwen Zhang
    • Hosung Jang
    • Robert J. Schmitz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Combining chemotherapeutics can be beneficial but identifying effective combinations from the vast array of possibilities is resource and time consuming. Here, the authors perform a high-throughput targeted CRISPR knock-out screen identify druggable gene targets which alter sensitivity to chemotherapies. In doing so, they identify DNA-PK inhibition as a sensitiser of neuroblastomas to doxorubicin.

    • Hyeong-Min Lee
    • William C. Wright
    • Paul Geeleher
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18