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Showing 1–4 of 4 results
Advanced filters: Author: Yonatan Eliezer Clear advanced filters

  • Human cancer cells often double their genome through an error in cell division, and this can lead to further genomic instability. A detailed analysis of the first cell cycle after genome doubling sheds light on this phenomenon.

    • Yonatan Eliezer
    • Uri Ben-David
    News & Views
    Nature
    Volume: 604, P: 44-45

  • Despite being a hallmark of cancer, the identification of targetable vulnerabilities of aneuploid cancer cells remains limited. Here, the authors develop RPE1-hTERT cell lines with varying degrees of aneuploidy to investigate the consequences of chromosomal imbalance, identifying CRAF as an aneuploid-selective therapeutically targetable vulnerability.

    • Johanna Zerbib
    • Marica Rosaria Ippolito
    • Stefano Santaguida
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.

    • Lorenza Garribba
    • Giuseppina De Feudis
    • Stefano Santaguida
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17