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Showing 1–8 of 8 results

Advanced filters: Author: YongJuan He Clear advanced filters

Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity

The authors show that the endoplasmic reticulum-phagy receptor FAM134B interacts with SCAP to regulate cholesterol biosynthesis, sequestering SCAP when endoplasmic reticulum cholesterol is high but dissociating upon low cholesterol levels, allowing SCAP to activate cholesterol synthesis.

Boran Li
Dongheng Zhou
Qiming Sun
Research13 Oct 2025
Nature Cell Biology

Volume: 27, P: 1739-1756
The shutdown of food digestion due to endoplasmic reticulum homeostasis disruption acts as a protective mechanism in C. elegans

This study shows that C. elegans can sense stress in the endoplasmic reticulum and shut down digestion as a protective response. A food-induced protein, FDR-1, helps maintain ER balance and prevent overload during nutrient intake.

YongJuan He
Yunqing Zhang
Bin Qi
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-17
Targeting p16^INK4a-mediated cellular senescence as a therapeutic strategy for FLT3-ITD-driven acute myeloid leukemia

Jiarui Zheng
Linlin Jin
Yingchi Zhang
Research21 Aug 2025
Leukemia

Volume: 39, P: 2652-2662
A novel nanoparticle vaccine displaying multistage tuberculosis antigens confers protection in mice infected with H37Rv

Yanbin Ding
Yuanyuan Li
Jing Jin
ResearchOpen Access29 Jul 2025
npj Vaccines

Volume: 10, P: 1-18
A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys

Treatments developed in small-animal models of stroke are often not translatable to the clinic. In this protocol, a blood clot in a microcatheter is introduced into the middle cerebral artery of rhesus monkeys; controlled thrombolysis is possible.

Di Wu
Jian Chen
Xunming Ji
Protocols27 Jun 2022
Nature Protocols

Volume: 17, P: 2054-2084
RETRACTED ARTICLE: Extracellular vesicle-associated microRNA-221-3p secreted by drug-resistant lung cancer cells targets HMBOX1 to promote the progression of lung cancer

Jun Li
Yongjuan Zhao
Jing Wang
Research20 Nov 2020
Cancer Gene Therapy

Volume: 28, P: 679-692
Root Physiological Traits and Transcriptome Analyses Reveal that Root Zone Water Retention Confers Drought Tolerance to Opisthopappus taihangensis

Yongjuan Yang
Yanhong Guo
Ming Sun
ResearchOpen Access14 Feb 2020
Scientific Reports

Volume: 10, P: 1-14
Intranasal immunization with inactivated chlamydial elementary bodies formulated in VCG-chitosan nanoparticles induces robust immunity against intranasal Chlamydia psittaci challenge

Zonghui Zuo
Yongjuan Zou
Francis O. Eko
ResearchOpen Access17 May 2021
Scientific Reports

Volume: 11, P: 1-17