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The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Current clinical systems for physiological monitoring face challenges in bulky tethers or percutaneous wires. Here, the authors present a tether-free and ultrathin piezoelectric resonator device that supports wireless, continuous measurement of arterial pulse, respiration, and intracranial pressure

Despite the ease of fine-tuning their reactivity, high-performance homogeneous photocatalysts competent for acetylene semihydrogenation are scarce. Here the authors introduce an effective cobalt catalyst for the production of polymer-grade ethylene, which is amenable to scale-up in a continuous-flow photoreactor.

Integrating functional materials with microfibers for optical tuning remains challenging. Here, the authors present a conformal strategy to integrate homogeneous and inhomogeneous nanomembranes—including metals, oxides, semiconductors and polymers—onto microfibers, which are further developed into on-fiber sensors, modulators, filters, and photodetectors.

Dipole–dipole interactions in mixed-phase CdZnSeS quantum dots enable the effective orientation of the quantum dots and improved photon out-coupling when employed in a light emitting diode.

The authors identify feimin as a feeding-induced myokine that regulates glucose homeostasis via the MERTK–AKT signalling axis in mice and humans.

Jiang et al. propose a kirigami-based, mechanically reconfigurable metasurface that utilizes simple uniform stretching to achieve unexpected and dynamic beam steering functions. This unique approach modifies the geometric phase and lattice constant synchronously based on the rotation of anisotropic meta-atoms, exhibiting extended degree of freedom and wave-tuning ranges.

Lithium–sulfur batteries are a promising electrochemical energy storage technology; however, they are limited by the dissolution of polysulfide intermediates. Now, it has been shown that sparingly solvating electrolytes containing a phase mediator can avoid polysulfide dissolution and accelerate surface-localized solution-phase sulfur reaction to improve battery performances.

Yao and Gong et al. identify WD40 repeat-containing protein 6 (WDR6) to be upregulated in the liver of insulin-resistant mice. WDR6 contributes to promoting hepatic de novo lipogenesis during insulin resistance by upregulation of fatty acid synthase, and the authors identify a small molecule to inhibit this effect of WDR6 and reduce hepatic steatosis.

USP9X is a deubiquitinating enzyme with many known substrates and functions; it has been linked to cancer but the mechanisms remain unclear. Here Liet al. report that USP9X stabilizes the centrosomal protein CEP131 leading to centrosome amplification and breast cancer development.

Zhang et al. report a quasistatic multilevel finite element model to predict the 3D structures assembled by 2D nanomembranes, validated by large-scale, high-yield, and configurable fabrication. 3D Si/Cr photodetectors assisted by neural network are employed to resolve the incident light angle.

Electromagnetic devices involving a vibratory actuator and a soft strain-sensing sheet can dynamically measure the Young’s modulus of skin and of other soft biological tissues at depths of millimetres.

Ustilaginoidea virens is a fungal pathogen that infects rice via the panicles. Here, the authors show that U. virens SGP1, a conserved Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored protein, elicits immune responses in rice leaves while contributing to virulence in panicles.

Using an integrated analysis on three independent large human datasets, Wang et al. map macroscale dysconnectivity in schizophrenia onto layer- and cell-type-specific microscale alterations. The authors identify different alterations of corticocortical and corticostriatal connectivity in schizophrenia and their relationship to different symptom dimensions and functional domains.

Population analysis of 516 wild and domesticated broomcorn millet genomes and a graph-based pangenome based on de novo assemblies of 32 representative accessions identify genomic variations associated with domestication traits.

A study using a copper-in-silver dilute alloy catalyst in a high-pressure gas flow reactor reports highly selective electrosynthesis of acetate from carbon monoxide.

Conventional solid-to-solid conversion cathodes in rechargeable aluminium batteries suffer from sluggish reaction kinetics and cumulative structural degradation. Here the authors disclose a solution-to-solid conversion chemistry using molten salt electrolytes to achieve fast-charging capability and good cycling stability.

A series of mesoscale supramolecular hexagonal grids have been constructed in solution through stepwise intra- then intermolecular coordination-driven self-assembly, and characterized with atomic resolution by scanning tunnelling microscopy and spectroscopy.

In this work, authors demonstrate a smart window combining mechanochromism with thermochromism by self-rolling of VO₂ nanomembranes to modulate in-door temperature self-adapted to seasons and climate with high efficiency.

The preparation of lanthanide-transition metal clusters containing multiple lanthanide atoms remains challenging. Here, the authors present the controlled on-surface formation of ligand-stabilized heterometallic Ce/Au clusters containing two, three and four Ce atoms bridged by Au adatoms.

The heterointerface between complex oxides and van der Waals materials presents a versatile platform for exploring new functionalities. Here, the authors report an unconventional nonlinear optical filtering effect resulting from the interfacial polar alignment between monolayer MoS₂ and a ferroelectric oxide thin film.

A new cross-validated neuroimaging biomarker that reflects striatal dysfunctioning can be used to distinguish patients with schizophrenia from healthy controls, and is associated with treatment response to antipsychotics.

A process is described for the transformation of bulk wood into a low-cost, strong, tough, lightweight structural material, by the partial removal of lignin and hemicellulose followed by hot-pressing to densify the natural wood.

Dongxin Lin and colleagues report a genome-wide association study for pancreatic cancer in Chinese populations. The authors identify five new genetic loci associated with risk of pancreatic cancer.

Cholangiocytes are the primary targets of cholangiopathies. This study elucidates the role of miR-200c in maintaining cholangiocyte homeostasis making use of cell culture and mouse models of cholestasis. MiR-200c restrains the proliferative and neuroendocrine-like activation of cholangiocytes by targeting sestrin 1(SESN1) and inhibiting the IL-6/AKT feedback loop to prevent cholestatic liver injury. The findings provide critical mechanistic insights into biliary liver fibrosis and suggest miR-200c may be a novel therapeutic target of cholangiopathies.