Cross-seeding of SEVI, a protein that enhances the infectivity of HIV virus, with Amyloid-β (Aβ) can prevent Aβ aggregation, disaggregate preformed Aβ fibrils, reduce Aβ-induced cell toxicity, and attenuate Aβ-accumulated paralysis in a transgenic C. elegans model of Alzheimer’s Disease.
- Yijing Tang
- Dong Zhang
- Jie Zheng