Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal domain of LDHA and its depletion inhibits invasion, self-renewal, tumorigenesis and chemoresistance of CRCSCs.
- Yapeng Ji
- Chuanzhen Yang
- Xiaofeng Zheng
