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Showing 1–3 of 3 results
Advanced filters: Author: Yongzhen Hei Clear advanced filters

  • The photostability of organic fluorophores attached to proteins is sensitive to their environment, yet the impact of nearby protein residues remains unclear. Here, the authors reveal that methionine, tryptophan, phenylalanine, valine, and leucine decrease the photostability of a maleimide-derived fluorophore attached to cysteine residues in proteins, while glutamate enhances it, and use molecular dynamics simulations to elucidate the underlying mechanisms.

    • Yongzhen Hei
    • Banglong Wang
    • Chunlai Chen
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-8

  • Single-molecule techniques can shed light on biochemical dynamics with high precision, but they require a significant photon number per frame and are hampered by the limited number of photons emitted by each fluorophore before photobleaching. Here, the authors introduce MUFFLE, a deep-learning denoising tool that enables single-molecule FRET with up to 10-fold reduction in photon requirement per frame.

    • Yu Miao
    • Yuxiao Cheng
    • Chunlai Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • The origin of Fc receptor-based phagocytosis is unknown, although plasma lipid redistribution after solid structure binding induces similar phagocytic signaling. Here, Mu et al. show that PIP2 accumulation from plasma membrane deformation recruits Moesin to trigger receptor-independent phagocytosis.

    • Libing Mu
    • Zhongyuan Tu
    • Yan Shi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16