This study reveals that the protein AKAP11 plays a crucial role in regulating neuronal signaling and synaptic function by linking PKA activity to autophagy. Loss of AKAP11 distorts compartment-specific PKA and GSK3α/β activities and impairs neurotransmission, highlighting a shared molecular pathway between bipolar disorder and schizophrenia.
- You-Kyung Lee
- Cong Xiao
- Zhenyu Yue
