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Showing 1–4 of 4 results
Advanced filters: Author: Youwei Ai Clear advanced filters
  • A groundbreaking study reveals how physical confinement triggers ferroptosis. It finds the nucleus acts as a mechanosensor, orchestrating Drp1 and cPLA2 that leads to mitochondrial dysfunction and ultimately, cell death.

    • Fang Zhou
    • Robert J. Ju
    • Congying Wu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Adenosine A3 receptor (A3AR) holds promise for treating inflammatory and cancer conditions. Here, Cai et al. present cryo-EM structures of  A3AR bound to agonists CF101 and CF102, offering insights into its activation and ligand interaction, crucial for developing targeted therapies.

    • Hongmin Cai
    • Shimeng Guo
    • H. Eric Xu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10
  • Multiparameter sensors in quantum optics are often complex due to use of external fields. Here the authors demonstrate a simple single-shot all-optical vector atomic magnetometer based on machine learning for the correspondence of the measured signals and the magnetic field.

    • Xin Meng
    • Youwei Zhang
    • Yanhong Xiao
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9
  • PDE3A modulators for cancer therapy cause serious side effects as they inhibit PDE3A phosphodiesterase activity, which is essential for the maturation of oocytes and the formation of platelets. Here, the authors identify a compound, nauclefine, that does not inhibit PDE3A activity but induces apoptosis by enabling a complex formation between PDE3A and SLFN12.

    • Youwei Ai
    • Haibing He
    • Xiangbing Qi
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10