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Acyclic azomethine imines would be useful prochiral electrophiles in catalytic asymmetric reactions, but their generation often requires harsh conditions. Here, they are generated under mild conditions in the presence of an axially chiral dicarboxylic acid, with the chiral counterion (the conjugate base) then directing an enantioselective reaction with a diazoacetate nucleophile.

The formation of chiral molecules generally relies on direct chirality transfer from catalyst to products. Here, the authors report a strategy based on point chirality transfer from the catalyst to a dirhodium carbene intermediate with axial chirality, which is then transferred to products via C(sp²)-H functionalization.

Serial femtosecond crystallography reveals the structural dynamics of photosystem II during the S-state transitions that produce dioxygen, providing insight into electron transfer, water insertion, proton release and O–O bond formation on sub-microsecond timescales.

Experimental systems in which non-trivial topology is driven by spontaneous symmetry breaking are rare. Now, topological gaps resulting from two excitonic condensates have been demonstrated in a three-dimensional material.

Palladium-based catalysts are highly effective for the complete oxidation of methane. Here, the authors employ operando transmission electron microscopy, near-ambient pressure X-ray photoelectron spectroscopy, and density functional theory calculations to investigate the active state and catalytic function of Pd nanoparticles in methane oxidation.

Machine learning can be used to identify subtypes of psychiatric disease. Here the authors identified two neurostructural subgroups in schizophrenia, each showing reproducibility and generalizability across different collection locations and illness stages, using the SuStain algorithm.

Observation of a faint Fermi surface inside the pseudogap of an electron-doped cuprate suggests that Cooper pairing is mediated by antiferromagnetic spin fluctuations.

In the absence of progranulin, microglia enter a disease-specific state that causes endolysosomal dysfunction and neurodegeneration, and these microglia promote TDP-43 granule formation, nuclear pore defects and cell death specifically in excitatory neurons via the complement activation pathway.

The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

XBB.1.5 of SARS-CoV-2 is a descendant of XBB.1 and has mutations in spike and ORF8, making it more infectious to humans. Here, the authors examined in detail the differences in virological properties of the two variants.

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

A high-precision angle-resolved photoemission spectroscopy (ARPES) study on the superconductor Bi2212 resolves the spectroscopic singularity associated with the superconducting transition temperature, and indicates that the transition is driven by phase fluctuations.

The presence of excitonic instability and its relationship with a structural transition in Ta₂NiSe₅ has been debated. Chen et al. map out the electronic bands and lattice distortion across the semimetal-to-semiconductor transition with sulfur doping, revealing the crucial role of electron-phonon coupling.

In quantum chromodynamics, the condensation of quark–antiquark pairs breaks the chiral symmetry of vacuum. Experiments with pionic tin atoms demonstrate that the symmetry is partially restored at high densities.

The interaction between antiferromagnetic magnons and electrons sits at the heart of many strongly correlated systems, however, investigation has been hampered by a lack of clear-cut examples. Here, Yu et al directly observe a kink in the dispersion, a result of renormalization due to the electron-antiferromagnetic magnon interaction.

JWST observations of the Cosmic Gems arc resolve the light of an infant galaxy into five gravitationally bound star clusters located in a region smaller than 70 pc.

JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion.

The controlled manipulation of the topological phases of electronic materials is a central goal of modern condensed matter research. Here, the authors demonstrate controllable switching between two distinct topological phases in a layered ferromagnet via thermal cycling.

Spinal muscular atrophy (SMA) is caused by a defect in the SMN1 gene, leading to muscle weakness and motor neuron loss. Here, the authors show that combining CRISPR-Cas9 genome editing with gene supplementation improves survival and motor function in SMA mice, highlighting a potential new treatment avenue.

The authors present ARPES and STM/STS measurements of the kagome superconductor CsV_3-xTa_xSb₅. For the x = 0.4 Ta-doped sample, they report evidence for a van Hove singularity perfectly aligned with the Fermi level, and that the superconducting transition temperature is maximized at this doping.

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Energy storage by metal redox reactions sets strict limits on capacity in metal oxide cathode materials used in lithium-ion batteries. Here authors study stabilization of redox reactions at oxygen sites and demonstrate a cathode with a high reversible capacity enabled by the process.

Photoelectron spectroscopy measurements uncover a singularity over a wide doping range in the cuprate superconductor Bi₂Sr₂CaCu₂O_8+δ, suggesting a competition between the charge-ordering and the superconducting phases.

Analysis of the antiferromagnetic ordered phase of kagome lattice FeGe suggests that charge density wave is the result of a combination of electronic-correlations-driven antiferromagnetic order and instability driven by van Hove singularities.

Ito et al. present CoVFit, an AI model that predicts variant fitness (transmissibility) from spike protein sequences alone. They further demonstrate its utility in forecasting viral evolution via single amino acid mutations.

The interplay of magnetism, various symmetries and correlations can lead to intriguing physics in the solid state. Here, the authors report signatures of a Hund nodal line in the antiferromagnet YMn₂Ge₂.

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.