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Showing 1–14 of 14 results
Advanced filters: Author: Yu-Cheng Chan Clear advanced filters

  • The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

    • Hung-Hsin Chen
    • Chien-Hsiun Chen
    • Cathy S. J. Fann
    ResearchOpen Access
    Nature
    Volume: 648, P: 128-137

  • Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

    • Chun-Yu Wei
    • Ming-Shien Wen
    • Pui-Yan Kwok
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • A zeolite-confined Cu single-atom cluster was developed for the electrochemical CO reduction application, which can achieve stable CO-to-acetate conversion at an industrial current density of 1 A cm−2 at 2.7 V with a high acetate Faraday efficiency for over 1,000 h at atmospheric pressure.

    • Yan Wen
    • Changhong Zhan
    • Xiaoqing Huang
    Research
    Nature Nanotechnology
    Volume: 20, P: 656-663

  • Solid-state lithium batteries typically utilize heterogeneous composite cathodes with conductive additives, which limit energy density and cycle life. Here the authors present a cathode material that exhibits efficient mixed conduction and near-zero volume change during cycling, thereby improving battery performance.

    • Longfei Cui
    • Shu Zhang
    • Guanglei Cui
    Research
    Nature Energy
    Volume: 9, P: 1084-1094

  • Designing an efficient electrocatalyst of hydrogen oxidation reaction is highly critical for anion exchange membrane fuel cells. Here the authors report implanting oxophilic metal atoms in PtRu nanowires to significantly improve the mass activity, stability, and resistance to CO-poisoning for hydrogen oxidation.

    • Zhongliang Huang
    • Shengnan Hu
    • Xiaoqing Huang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Lattice-oxygen redox is pivotal for high oxygen evolution reaction (OER) activity. Here, LiNiO2, a unary 3d-transition metal oxide catalyst, exhibits superefficient activity during the OER due to the creation of double O 2p holes states, according to operando XAS, XRD, and Raman spectroscopy observations.

    • Haoliang Huang
    • Yu-Chung Chang
    • Linjuan Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating  these collagen III/CD167a-driven metastatic foci.

    • Yu-Cheng Lee
    • Antonina V. Kurtova
    • Keith Syson Chan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • In this Review, the authors summarize current advances in our understanding of the roles of stroma and associated extracellular matrix during bladder cancer development, describing the bladder tumour microenvironment and introducing the concept of the metastatic tumour microenvironment.

    • Yu-Cheng Lee
    • Hung-Ming Lam
    • Keith Syson Chan
    Reviews
    Nature Reviews Urology
    Volume: 19, P: 515-533

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29