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Showing 1–4 of 4 results
Advanced filters: Author: Yu-Shuai Zhang Clear advanced filters

  • Achieving generality in asymmetric catalysis with highly reactive radicals is a challenge. Now it is shown that a sequential copper-catalysed approach enables the efficient, enantioselective cross-coupling of over 50 diverse radicals, providing unified access to C-, P- and S-chiral products and advancing the asymmetric synthesis of challenging molecular architectures.

    • Li-Wen Fan
    • Jun-Bin Tang
    • Xin-Yuan Liu
    Research
    Nature Chemistry
    Volume: 18, P: 142-151

  • A general copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of diverse racemic tertiary alkyl halides with terminal alkynes has been developed, forging all-carbon quaternary stereocentres. Key to the success is the rational design of chiral anionic N,N,N-ligands tailor-made for the computationally predicted outer-sphere radical group transfer pathway.

    • Fu-Li Wang
    • Chang-Jiang Yang
    • Xin-Yuan Liu
    Research
    Nature Chemistry
    Volume: 14, P: 949-957

  • Lipidomics profiling workflow. (a) Plasma lipidomics extraction was accomplished by fractionating samples into pools of species with similar physicochemical properties using appropriate combinations of organic solvents, after the addition of an internal standard. (b) UPLC-MS/MS-based platforms were used to perform optimal profiling of plasma lipidomics. Data preprocessing generated a list of chromatographic peak areas for the lipidomics detected in each sample injection. Inter- and intra-batch normalization was carried out with quality control (QC) calibration and internal standard correction. (c) Once normalized, univariate and multivariate data analyses were performed. (d) Selection of the best candidate biomarkers for the early diagnosis and efficacy evaluation of TB. (e) The results of this experiment provide four ideas for the research and development of potential antituberculotic medications, so as to achieve the purpose of antituberculosis treatment.

    • Jia-Xi Chen
    • Yu-Shuai Han
    • Ji-Cheng Li
    ResearchOpen Access
    Signal Transduction and Targeted Therapy
    Volume: 6, P: 1-11