Here, the authors report that SARS-CoV-2 M protein interacts with host ARF1 to facilitate viral assembly at the ER-Golgi intermediate compartment and demonstrate that targeting ARF1 or its interaction with the M protein disrupts virus production in vitro and in vivo, proposing a potential broad-spectrum therapeutic approach.
- Cunhuan Zhang
- Yuan-Qin Min
- Yun-Jia Ning
