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Showing 1–2 of 2 results
Advanced filters: Author: Yucong Bai Clear advanced filters

  • B7H3 is an immune checkpoint overexpressed in many cancers and associated with tumor immune evasion. Here, the authors discover that in colorectal cancer, particularly microsatellite-stable tumors, palmitic acid promotes ZDHHC24- mediated B7H3 palmitoylation, regulating CD8⁺ T cell antitumor activity.

    • Zejun Rao
    • Changsheng Huang
    • Xuelai Luo
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-24

  • Carbamoyltransferases are a class of enzymes catalyzing carbamoylation of primary and secondary metabolites. Here, the authors show the molecular structure of the ansamycin-modifying carbamoyltransferase GdmN and repurpose the enzyme for the iterative carbamoylation of ansamitocins.

    • Jianhua Wei
    • Xuan Zhang
    • Linquan Bai
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15