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Showing 1–1 of 1 results
Advanced filters: Author: Yuich Abe Clear advanced filters

  • Drug tolerance to KRAS inhibition remains a major challenge in cancer therapy. Here the authors find that KRAS inhibition induces a cellular state characterized by enhanced ribosome biogenesis in KRAS-mutant colorectal cancer cells and these cells are vulnerable to inhibition of RNA polymerase I.

    • Yui Tanaka
    • Mizuho Sakahara
    • Ryoji Yao
    ResearchOpen Access
    Nature Communications
    P: 1-16