Ribonucleoprotein (RNP) granules are membraneless organelles formed through the condensation of RNA and proteins, which serve critical functions in diverse biological processes and disease contexts. Identifying their RNA composition is vital for understanding their molecular functions and mechanisms of formation, yet conventional approaches often fail to fully capture the complexity of these granules. This review highlights recent advances in transcriptome profiling of RNP granules using biochemical purification and proximity labeling, offering new insights into their molecular roles.
- Yuichi Shichino
- Shintaro Iwasaki
