Yuji Okuno et al. find that pathological angiogenesis in mice requires dampening of oxidative stress. In the absence of the ATM protein kinase, increased oxidative stress leads to activation of the p38α protein kinase and inhibition of new blood vessel growth. These findings run counter to the commonly held concept that decreasing oxidative stress would inhibit pathological angiogenesis and suggest new targets for treating diseases involving abnormal blood vessel growth.
- Yuji Okuno
- Ayako Nakamura-Ishizu
- Yoshiaki Kubota
