Nature Search

Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis

The dietary fibre inulin is shown to promote fructose catabolism by the small intestinal microbiome, thereby mitigating fructose-induced hepatic lipogenesis and steatosis.

Sunhee Jung
Hosung Bae
Cholsoon Jang
ResearchOpen Access15 Sept 2025
Nature Metabolism

Volume: 7, P: 1801-1818
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H₂O₂⁻ production

Chun et al. find that a severe model of reactive astrocytes overproduces hydrogen peroxide, leading to the development of Alzheimer’s disease-like pathologies, including neurodegeneration, tauopathy and memory impairment.

Heejung Chun
Hyeonjoo Im
C. Justin Lee
Research16 Nov 2020
Nature Neuroscience

Volume: 23, P: 1555-1566
A compendium of chromatin contact maps reflecting regulation by chromatin remodelers in budding yeast

The effect of ATP-dependent chromatin remodelers on 3D genome organization has not been well studied. Here the authors employ in situ Hi-C with an auxin-inducible degron system to degrade chromatin remodelers in yeast to find that the 3D structure of chromatin collapses in their absence. The chromatin remodeling can modulate 3D architecture depending on chromosomal context and cell cycle stage.

Hyelim Jo
Taemook Kim
Daeyoup Lee
ResearchOpen Access04 Nov 2021
Nature Communications

Volume: 12, P: 1-11
Identification of a potent and selective covalent Pin1 inhibitor

A highly selective covalent peptide inhibitor of the peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is used to show that Pin1 cooperates with mutant KRAS to promote pancreatic ductal adenocarcinoma (PDAC) transformation.

Benika J. Pinch
Zainab M. Doctor
Nathanael S. Gray
Research01 Jun 2020
Nature Chemical Biology

Volume: 16, P: 979-987
A single gene of a commensal microbe affects host susceptibility to enteric infection

The interactions between gut bacteria and enteric pathogens are poorly understood. Here, Yoon et al. show that subinhibitory antibiotic treatment in a mouse model leads to overgrowth of an E. coli strain carrying a catalase-encoding gene that enhances infection with the human pathogen Vibrio cholerae.

Mi Young Yoon
Kyung Bae Min
Sang Sun Yoon
ResearchOpen Access13 May 2016
Nature Communications

Volume: 7, P: 1-11
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Bright visible light emission from graphene

Electrically biased suspended graphene devices show an intense electroluminescence in the visible range with a tunable emission spectrum.

Young Duck Kim
Hakseong Kim
Yun Daniel Park
Research15 Jun 2015
Nature Nanotechnology

Volume: 10, P: 676-681
Comparative characterization of 3D chromatin organization in triple-negative breast cancers

Taemook Kim
Sungwook Han
Daeyoup Lee
ResearchOpen Access05 May 2022
Experimental & Molecular Medicine

Volume: 54, P: 585-600
Mesenchymal stem cells exert their anti-asthmatic effects through macrophage modulation in a murine chronic asthma model

Ruth Lee Kim
Ji-Young Bang
Hye-Ryun Kang
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Shp2-mediated MAPK pathway regulates ΔNp63 in epithelium to promote corneal innervation and homeostasis

In this paper, the authors found that conditional ablation of Shp2 in mouse K14-positive corneal epithelium (Shp2^K14ce-cko) impairs corneal innervation and results in corneal epithelial thinning, which resembles neurotrophic keratopathy. Furthermore, the data indicate that Shp2 signaling plays a pivotal role in corneal epithelial homeostasis.

Yuka Okada
Yujin Zhang
Chia-Yang Liu
Research25 Oct 2019
Laboratory Investigation

Volume: 100, P: 630-642

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