Nature Search

ACLY inhibition promotes tumour immunity and suppresses liver cancer

Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of care.

Jaya Gautam
Jianhan Wu
Gregory R. Steinberg
ResearchOpen Access30 Jul 2025
Nature

Volume: 645, P: 507-517
Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tissues.

Youngmin A. Lee
Luke A. Noon
Scott L. Friedman
ResearchOpen Access23 Nov 2018
Nature Communications

Volume: 9, P: 1-12
An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

Here, using human liver chimeric mice, the authors describe perturbation of the diurnal transcriptome and epigenome of human hepatocytes during hepatitis C virus infection, affecting pathways mediating metabolic alterations, fibrosis, and cancer, and further show that the pathways remain affected in patients with advanced liver disease.

Atish Mukherji
Frank Jühling
Thomas F. Baumert
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma

Wang et al. apply a spatial omics N-glycan imaging method to identify altered glycosylation in hepatocellular cancer tissue and matched serum samples identifying alteration in over 50 proteins. Machine learning biomarker algorithms developed through multi-protein glycan analysis could serve as potential biomarkers for early detection.

Mengjun Wang
Stephane Grauzam
Anand S. Mehta
ResearchOpen Access03 Dec 2024
Communications Medicine

Volume: 4, P: 1-11
STIE: Single-cell level deconvolution, convolution, and clustering in in situ capturing-based spatial transcriptomics

In situ capturing-based spatial transcriptomics cannot precisely capture randomly located single cells, regardless of its spot resolution. Here, authors integrate spot-level gene expression with histology images, computationally achieving single-cell level spatial transcriptomics.

Shijia Zhu
Naoto Kubota
Yujin Hoshida
ResearchOpen Access30 Aug 2024
Nature Communications

Volume: 15, P: 1-18
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.

Emilie Crouchet
Simonetta Bandiera
Thomas F. Baumert
ResearchOpen Access17 Sept 2021
Nature Communications

Volume: 12, P: 1-19
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Hepatic stellate cells regulate hepatocyte functions via R-spondin 3.

Atsushi Sugimoto
Yoshinobu Saito
Robert F. Schwabe
ResearchOpen Access12 Mar 2025
Nature

Volume: 640, P: 752-761
The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial

Bavituximab is a genetically engineered IgG1 chimeric antibody that targets phosphatidylserine. Here the authors report the results of a single-arm phase 2 trial of bavituximab in combination with pembrolizumab (anti-PD1) for patients with unresectable hepatocellular carcinoma.

David Hsiehchen
Muhammad S. Beg
Adam C. Yopp
ResearchOpen Access11 Mar 2024
Nature Communications

Volume: 15, P: 1-10
Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

Daniel F. Hicks
Nicolas Goossens
Scott L. Friedman
ResearchOpen Access03 Mar 2017
Scientific Reports

Volume: 7, P: 1-8
The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

Rosa S. Kim
Daisuke Hasegawa
Scott L. Friedman
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Subpopulations of cytokine-producing and myofibroblastic hepatic stellate cells, identified by single-cell RNA sequencing, protect against or promote the development of hepatocellular carcinoma via high expression of hepatocyte growth factor or type I collagen, respectively..

Aveline Filliol
Yoshinobu Saito
Robert F. Schwabe
Research05 Oct 2022
Nature

Volume: 610, P: 356-365
The role of GATA2 in lethal prostate cancer aggressiveness

The endothelial transcription factor GATA2 has been reported to have a key role in driving prostate cancer aggressiveness. GATA2 overexpression in prostate cancer increases cellular motility and invasiveness, proliferation, tumorigenicity, and resistance to standard therapies. Thus, GATA2 is a highly attractive target for the development of novel treatments against lethal prostate cancer.

Veronica Rodriguez-Bravo
Marc Carceles-Cordon
Josep Domingo-Domenech
Reviews22 Nov 2016
Nature Reviews Urology

Volume: 14, P: 38-48
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.

Carla Eller
Laura Heydmann
Thomas F. Baumert
ResearchOpen Access01 Jun 2020
Nature Communications

Volume: 11, P: 1-17
Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma is an aggressive cancer of the bile duct with few treatment options and a below 10% five-year survival rate. Here Sia et al. show a novel FGFR2–PPHLN1 fusion and ARAFmutations that may represent future potential therapeutic targets.

Daniela Sia
Bojan Losic
Josep M. Llovet
Research22 Jan 2015
Nature Communications

Volume: 6, P: 1-11
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

Ectopic lymphoid structures develop at sites of chronic inflammation and are generally thought to be beneficial in the control of cancer. Pikarsky and colleagues show that these structures can instead nurture liver tumor progenitor cells.

Shlomi Finkin
Detian Yuan
Eli Pikarsky
Research01 Dec 2015
Nature Immunology

Volume: 16, P: 1235-1244
Improving immunotherapy for the treatment of hepatocellular carcinoma: learning from patients and preclinical models

Romain Desert
Fabio Gianonne
Thomas F. Baumert
ReviewsOpen Access03 Apr 2025
npj Gut and Liver

Volume: 2, P: 1-15
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

In a mouse model of prostate cancer it is found that that the TGF-β signalling pathway limits tumour progression and metastasis. Using markers of this pathway and other biologically relevant factors, a four-gene signature is identified that is associated with poorer clinical outcome and metastatic progression in several prostate cancer cohorts, especially in combination with other clinical parameters. This signature may prove useful for the development of a better prognostic test for those cases of prostate cancer in which deciding on the right treatment regime while avoiding over-treatment constitutes an important clinical challenge.

Zhihu Ding
Chang-Jiun Wu
Ronald A. DePinho
Research02 Feb 2011
Nature

Volume: 470, P: 269-273
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

Matthew Meyerson and colleagues report the whole-genome sequencing of primary colorectal tumors and matched adjacent non-tumor tissue from nine individuals with colorectal cancer. They identify a recurrent VTI1A-TCF7L2 fusion in 3% of colorectal cancers.

Adam J Bass
Michael S Lawrence
Matthew Meyerson
Research04 Sept 2011
Nature Genetics

Volume: 43, P: 964-968
Lin28 promotes transformation and is associated with advanced human malignancies

George Daley and colleagues show that Lin28 and Lin28B promote cellular transformation by repressing let-7 family members, leading to derepression of let-7 targets. They also find that LIN28 and LIN28B are overexpressed in ∼15% of primary human tumors and cancer cell lines and that their expression is associated with aggressive disease and poor prognosis across multiple tumor types.

Srinivas R Viswanathan
John T Powers
George Q Daley
Research31 May 2009
Nature Genetics

Volume: 41, P: 843-848
In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment

Hadassa Hirschfield
C Billie Bian
Yujin Hoshida
ResearchOpen Access05 Jan 2018
Experimental & Molecular Medicine

Volume: 50, P: e419
Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma

Kenichiro Enooku
Hayato Nakagawa
Kazuhiko Koike
ResearchOpen Access23 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumption

Alyx Vogle
Tongqi Qian
Costica Aloman
ResearchOpen Access12 Feb 2020
Scientific Reports

Volume: 10, P: 1-14
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

Svenja Sydor
Paul Manka
Lars P. Bechmann
ResearchOpen Access14 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

Stefanie J. Hectors
Mathilde Wagner
Bachir Taouli
ResearchOpen Access26 May 2017
Scientific Reports

Volume: 7, P: 1-12
Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases

Ruchi Bansal
Shigeki Nakagawa
Jai Prakash
ResearchOpen Access17 Nov 2017
Experimental & Molecular Medicine

Volume: 49, P: e396
Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization

Kentaro Inamura
Takeshi Fujiwara
Yuichi Ishikawa
Research27 Jun 2005
Oncogene

Volume: 24, P: 7105-7113

Search

ACLY inhibition promotes tumour immunity and suppresses liver cancer

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma

STIE: Single-cell level deconvolution, convolution, and clustering in in situ capturing-based spatial transcriptomics

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

The role of GATA2 in lethal prostate cancer aggressiveness

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

Improving immunotherapy for the treatment of hepatocellular carcinoma: learning from patients and preclinical models

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

Lin28 promotes transformation and is associated with advanced human malignancies

In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment

Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma

Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumption

Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases

Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization

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