********The authors engineered and constructed a circRNA containing both miR-21 and miR-93 binding sites, then deployed it against esophageal carcinoma. This novel multi-miR circular sponge significantly inhibits endogenous miR-21 and miR-93 activities, suppresses cellular proliferation, migration and tumor growth. These findings suggest an entirely new area of research based on developing synthetic circular RNA sponges as tools for miR-directed molecular therapy.
- Zhe Wang
- Ke Ma
- Stephen J. Meltzer
