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How site-specific tumor microenvironment (TME) drives the metastasis of high-grade serous ovarian cancer (HGSOC) remains unclear. Here, the authors employ an integrated single cell multi-omics approach to map the spatiotemporal heterogeneity of HGSOC metastasis TME and identify an interaction network within the TME driven by SELENOP⁺ macrophages and pre-exhausted CD8⁺ T cells.

Hydrogels can be integrated into skin bioelectronics, though balancing stability, mechanical properties, and breathability remains challenging. Here the authors design a crosslinked organohydrogel using a solvent replacement strategy integrated into on-skin sensors.

Administrative-driven hierarchical management (ADHM) encourages general practitioners to act as voluntary gatekeepers in China’s non-mandatory medical system. Here the authors show that ADHM lowers cardiovascular events, mortality, and healthcare costs in atrial fibrillation patients compared with usual care.

In this phase 4 trial, the authors compare the immunogenicity and safety of co-purified diphtheria, tetanus, and acellular pertussis combined vaccine (co-purified DTaP) to diphtheria and tetanus combined vaccine (DT) in 6-year-old Chinese children.

Intestinal motility disorders that can occur following small intestine resection often require regular monitoring. This study reports a biodegradable ultrasound contrast tape (BioUCT) that adheres to the intestine for high-contrast imaging for up to two weeks for non-invasive monitoring of postoperative intestinal motility.

The authors develop a molecular dopant to avoid the dimerization of the electron-selective material phenyl-C₆₁-butyric acid methyl ester, resulting in enhanced stability and efficiency in inverted perovskite solar cells.

This analysis performs comprehensive comparisons of 27 single-cell perturbation response prediction methods using 29 datasets under different test scenarios and against multiple evaluation metrics.

This study identifies four distinct polycystic ovary syndrome (PCOS) subtypes using unsupervised clustering analysis on data from 11,908 women and validated across five diverse cohorts. The subtypes show unique clinical features and suggest that subtype-specific management could enhance treatment precision for PCOS.

Multimodal large language models (MLLMs) hold promise for a range of medical applications. Here, the authors use MLLMs for 3D brain CT radiology report generation, demonstrating that combining anatomy-aware model fine-tuning with robust evaluation metrics establishes a comprehensive and effective framework.

Analysis of genomes in a phylogenetic context reveals a 350-million-year-old homomorphic sex chromosome in molluscs, probably maintained by regulation of reversible sex-biased genes and sex chromosome turnover.

Multinational enterprises exacerbated China’s regional carbon inequality over 1997–2012 but alleviated it by 2017, demonstrating potential to mitigate both emission volume and inequality via knowledge spillovers.

The role of human glioma IDH1 mutations in regulation of antiviral response is unclear. Here, the authors show that D2HG produced by mutant IDH1 inhibits IFN antiviral responses in glioma cells, which confers sensitivity to oncolytic virotherapy.

In a single-arm phase 2b trial, glecirasib, an oral KRAS-G12C inhibitor, had an overall response rate of 47.9% in patients with locally advanced or metastatic KRAS^G12C-mutated nonsmall-cell lung cancer.

Catheter-based pulmonary artery denervation (PADN) has achieved promising outcomes to treat pulmonary hypertension (PH). Here, the authors show stereotactic body radiotherapy is a novel noninvasive approach for PADN with improved pulmonary hemodynamics in both acute and chronic PH swine models.

Qu et al. report a self-assembled material with π-expanded conjugation to form hydrophilic ordered bilayer as hole selective layer for inverted perovskite solar cells. The enhanced interfacial charge extraction and transport enable certified efficiency of 26.39% and 25.21% for 7.15 mm² - and 99.12 mm² -devices, respectively.

Endothelin-1 activation after SARS-CoV-2 infection leads to vascular permeability, chondrocyte senescence, osteoclast activation and cyst formation in affected joints of hamsters, which can be alleviated using macitentan. Joint injury was also seen in two patients after COVID-19 infection.

The online food delivery and takeaway market is growing in China, serving 406 million customers with 10.0 billion orders in 2018. Here, data from an online food delivery platform, life-cycle environmental impacts of packaging and tableware waste generated across 353 cities in China, and scenarios for paper alternatives and tableware sharing are presented.

Globally, concrete materials are widely used to build urban settings, resulting in massive waste. The authors propose scenarios of industrial-scale application of concrete nitrogenation, to use concrete debris in cities to mitigate NO_x emissions.

The authors demonstrate a high-speed silicon photonic transmitter employing on-chip adaptive dispersion compensation through integrating Mach-Zehnder modulators with tunable chirp control, enabling energy-efficient, high-capacity optical interconnects.

Ribosome biogenesis is crucial for maintaining stem cell homeostasis. Here, authors reveal that DDX10 plays a critical role in ribosome biogenesis by regulating 18S rRNA maturation, which is vital for the proliferation and maintenance of mESCs.

Chirality transfer by chemical self-assembly has been studied intensively for years but chirality transfers along the same path remains elusive. Here the authors use a multiscale chemo-mechanical model to elucidate the mechanism underlying the chirality transfer via self-assembly in hierarchical camphorsulfonic acid doped polyaniline.

The rapid deployment of low-carbon measures is urgently needed to reduce cement emissions as cement CO₂ emissions from developing countries will almost deplete the remaining cement emissions budget within climate targets.

Exo-selective Diels–Alderases with a broad substrate scope for synthetically valuable reactions are lacking. Now, a highly exo-selective Diels–Alderase compatible with a wide range of diene and dienophile substrates is discovered, its X-ray structure solved and the catalytic mechanism defined.

Bivalve molluscs have evolved various characteristics to adapt to benthic filter-feeding. Here, Li et al investigate the genome, transcriptomes and proteomes of scallop Chlamys farreri, revealing evidences of molecular adaptations to semi-sessile life and neurotoxins.

Blade-coating produces large-area perovskite solar cells, but device performance is often reduced as the area of the film increases. Here, an additive is used to control film crystallization to achieve high power conversion efficiency, attributed to a self-deposited passivation method

In China, about 10 percent of industrial sectors are the least efficient water users across 343 prefectures, and water savings opportunities exist in agriculture, the clothing and chemical industry, according to an analysis that uses water withdrawal data.

Wang and colleagues identify a protein phosphatase role for the metabolic enzyme fructose-1,6-bisphosphatase 1 that, upon phosphorylation by PERK, dephosphorylates histone H3 and modulates PPARα-mediated gene expression to inhibit liver cancer progression.

Liu et al. demonstrate that CK2 phosphorylates CLOCK to promote its nuclear exportation and cytosolic accumulation, thereby acetylating and stabilizing PRPS1/2 and enhancing de novo nucleotide synthesis to facilitate liver tumour growth.

Si anodes could be an alternative to Li anodes in the application of solid-state batteries, but they suffer from issues such as severe volume expansion and sluggish kinetics. Here the researchers develop a Li–Si alloy anode that is stabilized by hard carbon, which leads to exceptional high-performance solid-state batteries.

Wu et al. show that, upon activation by insulin-like growth factor 1 receptor and AKT, creatine kinase B exhibits a moonlighting function as protein kinase to phosphorylate glutathione peroxidase 4 to prevent its degradation, thereby suppressing ferroptosis and enhancing tumour growth in mice.

Surface-enhanced Raman spectroscopy (SERS) is a promising technology for sensitive optical sensors, generally using rough metal films. Here, Liu et al. synthesize high-quality graphene quantum dot films which offer a large SERS enhancement due to a strong light-matter interaction with Van Hove singularities.

By using an integrated omics approach, a landscape of metabolic remodelling of early-stage mouse embryogenesis is reconstructed, identifying key metabolites for epigenetic reprogramming.

The rapid spread of solar power plants onto cropland is having increasingly detrimental impacts. Targeted policy and technological solutions are urgently needed to resolve the tension between renewable energy and food production.

Single-cell RNA sequencing identifies a fibroblast gene signature promoting T-cell infiltration in muscle-invasive bladder cancer.

Li Yu, Ya-Ping Zhang, Chung-I Wu and colleagues report the de novo genome of the black snub-nosed monkey Rhinopithecus bieti and the genomic sequences of four other Rhinopithecus species, including three high-altitude and two lowland species. The species- and population-level genomic analyses as well as the transcriptomic analysis and functional assays find adaptive signatures associated with adaptation to high altitude.