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Showing 1–8 of 8 results
Advanced filters: Author: Yulia Nefedova Clear advanced filters

  • Pathologically activated neutrophils, termed myeloid-derived suppressor cells, in the tumour microenvironment spontaneously undergo ferroptosis, which negatively regulates anti-tumour immunity through the release of oxygenated lipids, therefore limiting the activity of human and mouse T cells.

    • Rina Kim
    • Ayumi Hashimoto
    • Dmitry I. Gabrilovich
    Research
    Nature
    Volume: 612, P: 338-346

  • The role of type I interferon signalling in the control of myeloid derived suppressor cells (MDSC) activity remains controversial. Here the authors show that downregulation of type I interferon receptor is observed in MDSC from cancer patients and tumor-bearing mice and is required for the activation of their immune suppressive properties.

    • Kevin Alicea-Torres
    • Emilio Sanseviero
    • Dmitry I. Gabrilovich
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The lipid transporter FATP2 reprograms neutrophils to polymorphonuclear myeloid-derived suppressor cells by mediating the uptake of arachidonic acid and promoting the synthesis of prostaglandin E2.

    • Filippo Veglia
    • Vladimir A. Tyurin
    • Dmitry I. Gabrilovich
    Research
    Nature
    Volume: 569, P: 73-78

  • Dendritic cells in individuals with cancer and in mouse tumor models show an increase in triacylglycerides that seems to impair their antigen-processing capability and could thus contribute to tumor immune tolerance. This aberrant lipid load results from tumor-induced elevation of the scavenger receptor Msr1 on dendritic cells, and it can be targeted therapeutically to improve the efficiency of anticancer vaccines.

    • Donna L Herber
    • Wei Cao
    • Dmitry I Gabrilovich
    Research
    Nature Medicine
    Volume: 16, P: 880-886

  • Neutrophils are linked to tumor progression. Gabrilovich and colleagues demonstrate that neutrophils have tumor-stage-dependent alterations in motility, function and metabolism: in early phases, they are highly motile with altered metabolism, whereas at later stages, they become highly suppressive.

    • Sima Patel
    • Shuyu Fu
    • Dmitry I. Gabrilovich
    Research
    Nature Immunology
    Volume: 19, P: 1236-1247