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Showing 1–3 of 3 results
Advanced filters: Author: Yun-Huai Kuo Clear advanced filters

  • A quantitative fluorescence-activated cell sorting method for generating fully human conformational antibodies against amyloid aggregates associated with neurodegenerative disorders—without the need for immunization—has now been developed. Engineered antibodies obtained using this approach show properties rivaling those of clinical-stage antibodies specific for tau and α-synuclein amyloid aggregates.

    • Alec A. Desai
    • Jennifer M. Zupancic
    • Peter M. Tessier
    Research
    Nature Chemical Biology
    Volume: 21, P: 916-925

  • De novo designed interleukin-4 mimetics were engineered that induce biased signaling activation and exhibit high thermal stability. These mimetics offer insight into cytokine signaling and can be directly incorporated into 3D-printed biomaterials

    • Huilin Yang
    • Umut Y. Ulge
    • Jamie B. Spangler
    Research
    Nature Chemical Biology
    Volume: 19, P: 1127-1137