Amphiphilic Janus camptothecin-floxuridine (CF) conjugate was synthesized for engineering CF microbubbles (CF MBs) with ultrahigh drug-loading contents. CF MBs exhibited excellent capability to enhance ultrasound (US) imaging for identifying the location and size of the tumors, while it can be efficiently converted into CF NPs upon sonication, conducing to remarkably high drug tumor accumulation via sonoporation effect. Both camptothecin (CPT) and floxuridine (FUDR) could be released at an exact 1:1 ratio in the tumor microenvironment, achieving significantly improved therapeutic efficacy. Overall, the CF MBs combining with US technique will provide a step toward the application of targeted theranostics.
- Xiaolong Liang
- Yunxue Xu
- Zhifei Dai
