Nature Search

Prevalence and clinical significance of guideline-directed medical therapy in acute heart failure with reduced or mildly reduced ejection fraction

Yutaro Miyoshi
Takao Kato
Takeshi Kimura
ResearchOpen Access13 Jan 2026
Scientific Reports

Volume: 16, P: 1-11
Phase Separation Process in Polymer Systems III. Spinodal Decomposition in the Critical Mixture of Polystyrene and Poly(methylphenylsiloxane) and Scaling Analysis

Shuichi Nojima
Yutaka Ohyama
Takuhei Nose
Research01 Nov 1982
Polymer Journal

Volume: 14, P: 907-912
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction

Masayuki Shiba
Takao Kato
Takeshi Kimura
ResearchOpen Access16 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein

Tardigrades are resistant to extreme environmental conditions including dehydration, radiation and the vacuum of space. Here the authors present a high-quality genome which displays minimal horizontal gene transfer, and identify the unique tardigrade protein Dsup which suppresses DNA damage.

Takuma Hashimoto
Daiki D. Horikawa
Takekazu Kunieda
ResearchOpen Access20 Sept 2016
Nature Communications

Volume: 7, P: 1-14
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Manipulation and assembly of small objects in liquid crystals by dynamical disorganizing effect of push-pull-azobenzene-dye

Seiji Kurihara
Kazuhiro Ohta
Sun-Nam Kim
ResearchOpen Access09 Jul 2013
Scientific Reports

Volume: 3, P: 1-6
Urinary Oligosaccharide Excretion in Nephrotic Syndrome

Yukitoshi Takahashi
Shirou Omiya
Tadao Orii
Research01 Oct 1993
Pediatric Research

Volume: 34, P: 429-434
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Association between body mass index and prognosis of patients hospitalized with heart failure

Yuta Seko
Takao Kato
Takeshi Kimura
ResearchOpen Access07 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
Correction: Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer

Taichi Kuwahara
Shoichi Hazama
Hiroaki Nagano
Amendments and CorrectionsOpen Access17 Oct 2019
British Journal of Cancer

Volume: 121, P: 983-984
Trunk orthosis with joints providing resistive force improves dynamic sagittal alignment in postoperative patients with lumbar spinal stenosis

Tatsuya Igawa
Ken Ishii
Haruki Funao
ResearchOpen Access24 Nov 2023
Scientific Reports

Volume: 13, P: 1-9
Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure

Takao Kato
Hidenori Yaku
Takeshi Kimura
ResearchOpen Access24 Feb 2020
Scientific Reports

Volume: 10, P: 1-10
Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer

Taichi Kuwahara
Shoichi Hazama
Hiroaki Nagano
ResearchOpen Access06 Sept 2019
British Journal of Cancer

Volume: 121, P: 659-665
Polymer functionalization by luminescent supramolecular gels

This review focuses on supramolecular gelation that exhibits unique optical functionality through the highly ordered aggregation of low-molecular-weight compounds. The supramolecular gels can be applied to improve the functionality of polymer materials through nanofibrillar network formation, while maintaining transparency. We discuss concepts and methods for manufacturing supramolecular gels, their optical characteristics and their applications for light management technology.

Hirotaka Ihara
Makoto Takafuji
Yutaka Kuwahara
Reviews01 Jun 2016
Polymer Journal

Volume: 48, P: 843-853
Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

Kei Asayama
Takayoshi Ohkubo
Yutaka Imai
Research16 Aug 2012
Hypertension Research

Volume: 35, P: 1102-1110

Search

Prevalence and clinical significance of guideline-directed medical therapy in acute heart failure with reduced or mildly reduced ejection fraction

Phase Separation Process in Polymer Systems III. Spinodal Decomposition in the Critical Mixture of Polystyrene and Poly(methylphenylsiloxane) and Scaling Analysis

Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein

Blood DNA virome associates with autoimmune diseases and COVID-19

Manipulation and assembly of small objects in liquid crystals by dynamical disorganizing effect of push-pull-azobenzene-dye

Urinary Oligosaccharide Excretion in Nephrotic Syndrome

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Association between body mass index and prognosis of patients hospitalized with heart failure

Correction: Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer

Trunk orthosis with joints providing resistive force improves dynamic sagittal alignment in postoperative patients with lumbar spinal stenosis

Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure

Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer

Polymer functionalization by luminescent supramolecular gels

Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

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