Huang et al. identify that lnc-Snhg18 promotes BMSCs osteogenesis by facilitating Cav1–Ywhah interaction and Yap nuclear translocation. Loss of Snhg18 worsens bone loss, while delivery restores bone mass, suggesting a therapeutic target for osteoporosis.
- Jie Huang
- Yuteng Weng
- Zuolin Wang